DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Smok3a

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001119517.1	Gene:	Smok3a / 545814	MGIID:	3693943	Length:	504	Species:	Mus musculus

Alignment Length:	460	Identity:	118/460 - (25%)
Similarity:	200/460 - (43%)	Gaps:	95/460 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIK----------MVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNG 214
            |||.:.::          :..:|:|.:.:|.|....||.|.:......:|||.:.||:.     .
Mouse     6 QQKSEKLRSKSPLADMDGLHAQYVMLETIGHGGCATVKLAQHRLTGTHVAVKTIRKREY-----W 65

  Fly   215 EQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAH-- 277
            ...|..|:.||....|.:::.|:.|:  |.|:|:||:||.|.|...    ||..::....|.|
Mouse    66 CNRVISEVELLMMADHPNIISLLQVI--ETKKKVYLIMELCKGKSL----YQHIRKAGYLQEHEA 124

  Fly   278 -GYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGV------AEQLDLFAPDDTCTT 335
             ..||||:..:.|.|:..::|:|:||.|:::..|..:||.|||:      .::|:||.
Mouse   125 RALFKQLLSAMNYCHNQGIVHRDLKPDNIMVEKDGKVKIIDFGLGTKVKPGQKLNLFC------- 182

  Fly   336 GQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAW 400
              |:..|..||:... ..:.|.|:|:|:.||.||.:.||:.||:..:|.:|::.|..|::..|:
Mouse   183 --GTYPFSAPEVLLS-TPYDGPKIDVWTLGVVLYFMVTGKIPFDACSIKKLVKRILAGKYSIPS- 243

  Fly   401 LYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPI-PIP-----PLKGDKYRNS 459
              .:.|:..:|:..::.|:|..|.::.|:....|     |..|..: |.|     |||.|    .
Mouse   244 --RLSAELQDLLSLLMTANPKLRPTVAEVMVHPW-----VTEGSGVFPDPCEEQTPLKPD----P 297

  Fly   460 TVIPYLEAYHYGTQEEDVYFTEHDVNQELARQAAAAASEIRAKQSAAALAACH----------TY 514
            .::..:.  |.|.|.:|:   |..:.|....|..|:...:: ||   .|..|.          :.
Mouse   298 AIVKAMG--HIGFQAQDI---EDSLRQRKFNQTMASYCLLK-KQ---ILKECDRPTRARPVNPSV 353

  Fly   515 EPPSTSAAAASNSLGNGSREEAP----------VKKKGSALKRRAKKLTSCISV--------RKL 561
            .|..:....|:..||...||..|          |...|.:..::..:..|..||        ..:
Mouse   354 TPFPSLVDTATTRLGLRRRENEPTCPWSSANRQVSVCGKSTSKKRDRRVSWPSVLGRPRHTAPTM 418

  Fly   562 SHCRT 566
            .|.||
Mouse   419 DHTRT 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	79/271 (29%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	77/265 (29%)
Smok3a	NP_001119517.1	STKc_AMPK-like	27..275	CDD:270905	79/271 (29%)
		UBA_MARK_Par1	295..334	CDD:270522	9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..421		4/31 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..468
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910