DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Brsk1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001120809.1	Gene:	Brsk1 / 499073	RGDID:	1563268	Length:	778	Species:	Rattus norvegicus

Alignment Length:	283	Identity:	105/283 - (37%)
Similarity:	161/283 - (56%)	Gaps:	17/283 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            ||.|.:...||:|..|.||..::.....::||||:.:.||..  :....|.||||:||.::|.||
  Rat    31 VGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSE--SVLMKVEREIAILKLIEHPHV 93

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            ::|.||.  |.|:.:|||:|:..||  |:.||...| |:...:|..:|:|:|..|::.||..:.|
  Rat    94 LKLHDVY--ENKKYLYLVLEHVSGG--ELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICH 154

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIW 362
            :|:||.||||.....::|:|||:|   .|...|....|..|||.:..||:..| |.:.|.:.|:|
  Rat   155 RDLKPENLLLDEKNNIRIADFGMA---SLQVGDSLLETSCGSPHYACPEVIKG-EKYDGRRADMW 215

  Fly   363 SSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQ 427
            |.||.|:.|..|..||:.||:.:|||.:.||.:..|.::   ..|..:|:.||::.:|.|||||:
  Rat   216 SCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFI---PPDCQSLLRGMIEVEPEKRLSLE 277

  Fly   428 EIRHDTWFRSAPVKTGP---PIP 447
            :|:...|:.....:..|   |.|
  Rat   278 QIQKHPWYLGGKHEPDPCLEPAP 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	99/263 (38%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	98/257 (38%)
Brsk1	NP_001120809.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		STKc_BRSK1_2	32..285	CDD:270983	100/265 (38%)
		S_TKc	34..284	CDD:214567	99/262 (38%)
		UBA_BRSK	314..367	CDD:270525
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	362..548
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..778
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910