DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and CaMKII

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	80/281 - (28%)
Similarity:	132/281 - (46%)	Gaps:	41/281 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 YIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVEL 236
            |.:.:.||:|::..||..:........|.||:..:||  .....|.:.||..:.::|.|.::|.|
  Fly    14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKL--TARDFQKLEREARICRKLHHPNIVRL 76

  Fly   237 VDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQ------------AHGYFKQLVDGLEY 289
            .|.:  :|:...|||.:...||             .||:            |....:|:::.:.:
  Fly    77 HDSI--QEENYHYLVFDLVTGG-------------ELFEDIVAREFYSEADASHCIQQILESVNH 126

  Fly   290 LHSCRVIHKDIKPGNLLL---SLDQTLKISDFGVAEQLDLFAPDDTCTTG-QGSPAFQPPEIANG 350
            .|...|:|:|:||.||||   :....:|::|||:|.::.   .|.....| .|:|.:..||:..
  Fly   127 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQ---GDHQAWFGFAGTPGYLSPEVLK- 187

  Fly   351 HETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWE--APAWLYEMDADFANLIL 413
            .|.: |..||||:.||.||.|..|..||..::.:||...|..|.::  :|.| ..:..:..|||.
  Fly   188 KEPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEW-DTVTPEAKNLIN 250

  Fly   414 GMLQADPSKRLSLQEIRHDTW 434
            .||..:|:||::..|.....|
  Fly   251 QMLTVNPNKRITAAEALKHPW 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	80/281 (28%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	79/275 (29%)
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	80/281 (28%)
		S_TKc	14..272	CDD:214567	80/281 (28%)
		CaMKII_AD	390..517	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930