Protein Alignment Lkb1 and par-1

DIOPT Version :9

• Sequence 1: NP_001163606.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_995894.2
• Gene: par-1 / 2768852
• FlyBaseID: FBgn0260934
• Length: 1170
• Species: Drosophila melanogaster
• Alignment Length: 614
• Identity: 160/614 - (26%)
• Similarity: 245/614 - (39%)
• Gaps: 147/614 - (23%)

  Fly    13 AAGGAEAGGAGATGQMTVTTMEAQVKAAH-HHHLHHPTGGGAQHKVEEEEPDPVEDEMTVLLANK 76
            |:|.|..||.|:..|...|...:.....| |.|.|       ||
  Fly   125 ASGAAATGGVGSVSQGPATVSASAANTNHSHQHSH-------QH--------------------- 161

  Fly    77 NFHYDVASDL-DDDAFVELKEDTAQADDA---------GAGVGFYNPDELLLDDQPHPQVTWLDD 131
              |:.||::: .|.|.:........|..|         |:||.......:|.....||..
  Fly   162 --HHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSA----- 219

  Fly   132 DEIETLDRVTLDMG--NMFFNRVDSQDIIYQQKKKSIKM--------VGKYIMGDVLGEGSYGKV 186
                ...|.:...|  ||             |.:.|..|        :|||.:...:|:|::.||
  Fly   220 ----IKQRTSSAKGSPNM-------------QMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKV 267

  Fly   187 KEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLV 251
            |.|.:......:|:||:.|.:|.  |...|.:.||:.::|.|.|.::|:|..|:  |.::.:||:
  Fly   268 KLAKHLPTGKEVAIKIIDKTQLN--PGSLQKLFREVRIMKMLDHPNIVKLFQVI--ETEKTLYLI 328

  Fly   252 MEYCVGGLQEMIDYQP-DKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKI 315
            |||..||  |:.||.. ..||...:|...|:|:|..::|.|..|:||:|:|..||||..:..:||
  Fly   329 MEYASGG--EVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKI 391

  Fly   316 SDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEG 380
            :|||.:.:   |.|.....|..|||.:..||:..| :.:.|.:||:||.||.||.|.:|..||:|
  Fly   392 ADFGFSNE---FTPGSKLDTFCGSPPYAAPELFQG-KKYDGPEVDVWSLGVILYTLVSGSLPFDG 452

  Fly   381 DNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTW----FRSAPVK 441
            ..:..|.|.:.||::..|   :.|..|..||:...|..:|:||.||:.|..|.|    |....:|
  Fly   453 STLRELRERVLRGKYRIP---FYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELK 514

  Fly   442 --------TGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEEDVYFT-------EHDVNQELARQ 491
                    ...|..|..|....|..|.:...|....|    :||:.|       ..|...:.:|.
  Fly   515 PYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRY----DDVFATYLLLGRKSTDPESDGSRS 575

  Fly   492 AAAAASEIRAKQSAAALAACHTYEPP-----------------------------STSAAAASNS 527
            .::.:....:...|.|.|...:.:.|                             :.:.|||:.:
  Fly   576 GSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGA 640

  Fly   528 LG--------NGSREEAPVKKKGSALKRR 548
            :|        |.:...|.....||..||:
  Fly   641 VGAVNPSNNYNAAGSAADRASVGSNFKRQ 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	96/267 (36%)
		STKc_LKB1	178..435	CDD:271021	95/261 (36%)
par-1	NP_995894.2	STKc_MARK	252..504	CDD:270974	96/264 (36%)
		S_TKc	253..504	CDD:214567	95/263 (36%)
		UBA_MARK_Par1	525..563	CDD:270522	10/41 (24%)
		MARK1-3_C	839..936	CDD:213381

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910