Protein Alignment Lkb1 and Smok2b

DIOPT Version :9

• Sequence 1: NP_001163606.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001161385.1
• Gene: Smok2b / 236574
• MGIID: 3037705
• Length: 484
• Species: Mus musculus
• Alignment Length: 502
• Identity: 114/502 - (22%)
• Similarity: 193/502 - (38%)
• Gaps: 143/502 - (28%)

  Fly   171 KYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVE 235
            :|:|.:.:|.|...||..|.:......:|||::.|.:....|     |..|:.||....|.:::.
Mouse     7 QYVMLETIGHGGCSKVMLARHRLTGSHVAVKMIRKSECWCNP-----VMSEVELLMMADHPNIIS 66

  Fly   236 LVDVLYNEEKQKMYLVMEYCVG-GLQEMID----YQPDKRMPLFQAHGYFKQLVDGLEYLHSCRV 295
            |:.|:  |.|:|:||:||.|.| .|.:.|.    .|.|      :|...||||:..:.|.|:..:
Mouse    67 LLQVI--ETKKKVYLIMELCEGKSLYQHIRNAGYLQED------EARALFKQLLSAMNYCHNQGI 123

  Fly   296 IHKDIKPGNLLLSLDQTLKISDFGVAEQ------LDLFAPDDTCTTGQGSPAFQPPEIANGHETF 354
            :|:|:||.|:::..|..:||.|||:..|      |:||.         |:..|..||:... ..:
Mouse   124 VHRDLKPDNIMVEKDGKVKIIDFGLGTQVKPGQKLNLFC---------GTYPFSAPEVLLS-RPY 178

  Fly   355 AGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQAD 419
            .|.|:|:|:.||.||.:.||:.||:..:|.:|:..|..|::..|:   .:..:..:||..::.|:
Mouse   179 DGPKIDVWTLGVVLYFMVTGKVPFDAASIQKLVRQILAGKYFVPS---RLSVELRDLISLLMTAN 240

  Fly   420 PSKRLSLQEIRHDTWF------------RSAPVKTGP---------------------------- 444
            |..|.::.|:....|.            ...|:|..|
Mouse   241 PKLRPTVAEVMVHPWVTEGSGVFPDPCEEQMPLKPNPAIVKAMGYIGFQAQDIEDSLRQRKFNET 305

  Fly   445 -----------------PIPIPPLKGDKYRNSTVIPY-----LEAYHYGTQEEDVYFTEHDVNQE 487
                             ||...|:      |.:|.|:     ...:|.|.:..:...|  .:...
Mouse   306 MASYCLLKKQILKECDRPIRAQPM------NPSVTPFPSLVDTSTFHLGLRRRETEPT--SLRLS 362

  Fly   488 LARQAAAAASEIRAKQ---------SAAALAACHTYEPPST------------------SAAAAS 525
            ..||.:........|:         |...|...||.:...|                  |:..::
Mouse   363 ANRQMSVCGRSTSKKRDRRFSWPSVSGRPLHTTHTMDHTHTRTRSVPCIYSMFCTIQPNSSDDST 427

  Fly   526 NSLGNGSREEAPVKKKG---------SALKRRAKKLTSCISVRKLSH 563
            ....:.|.|:.||:.:|         ..:....:||..||..::.||
Mouse   428 EGHTSASAEDKPVRSRGWPRGIKGWTRKIGNVMRKLCCCIPSKETSH 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	81/273 (30%)
		STKc_LKB1	178..435	CDD:271021	79/267 (30%)
Smok2b	NP_001161385.1	STKc_AMPK-like	7..255	CDD:270905	81/273 (30%)
		S_TKc	8..256	CDD:214567	81/273 (30%)
		UBA_MARK_Par1	275..314	CDD:270522	1/38 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	356..400		8/45 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..450		6/27 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910