DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Mark4

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_758483.1	Gene:	Mark4 / 232944	MGIID:	1920955	Length:	752	Species:	Mus musculus

Alignment Length:	411	Identity:	119/411 - (28%)
Similarity:	192/411 - (46%)	Gaps:	64/411 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            ||.|.:...:|:|::.|||.|.:......:|:||:.|.:|.  |:..|.:.||:.::|.|.|.::
Mouse    56 VGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PSSLQKLFREVRIMKGLNHPNI 118

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDK-RMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |.::.:||||||...|  |:.||.... ||...:|...|:|:|..:.|.|...::|
Mouse   119 VKLFEVI--ETEKTLYLVMEYASAG--EVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVH 179

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDT-CTTGQGSPAFQPPEIANGHETFAGFKVDI 361
            :|:|..||||..:..:||:|||.:.:..|.:..|| |    |||.:..||:..| :.:.|.:|||
Mouse   180 RDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFC----GSPPYAAPELFQG-KKYDGPEVDI 239

  Fly   362 WSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSL 426
            ||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|..:::...|..:|:||.:|
Mouse   240 WSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVP---FYMSTDCESILRRFLVLNPAKRCTL 301

  Fly   427 QEIRHDTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEED------------VYF 479
            ::|..|.|     :..|            |....:.||.|      .|||            :.:
Mouse   302 EQIMKDKW-----INIG------------YEGEELKPYTE------PEEDFGDTKRIEVMVGMGY 343

  Fly   480 TEHDVNQELARQ----------AAAAASEIRAKQSAAALAACHTYEPPSTSAAAASNSLGNGSRE 534
            |..::.:.|..|          .....:|....:.|..||......|..|:...:|:   .||..
Mouse   344 TREEIKEALTNQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSS---KGSSH 405

  Fly   535 EAPVKKKGSALKRRAKKLTSC 555
            ....:...|...|:.:....|
Mouse   406 NKGQRASSSTYHRQRRHSDFC 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	93/264 (35%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	92/258 (36%)
Mark4	NP_758483.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		STKc_MARK	58..310	CDD:270974	94/270 (35%)
		S_TKc	59..310	CDD:214567	94/269 (35%)
		UBA_MARK3_4	328..370	CDD:270590	4/41 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..615		8/45 (18%)
		MARK4_C	654..752	CDD:213382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910