DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Stk11

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_035622.1	Gene:	Stk11 / 20869	MGIID:	1341870	Length:	436	Species:	Mus musculus

Alignment Length:	427	Identity:	226/427 - (52%)
Similarity:	296/427 - (69%)	Gaps:	26/427 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 FFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIP 212
            |.:|:||.::|||.::|..|::|||:|||:|||||||||||.::||.|||.|||||.|:||||||
Mouse    25 FIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89

  Fly   213 NGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAH 277
            |||.||.:||.||::|:||:|::||||||||||||||:||||||.|:|||:|..|:||.|:.|||
Mouse    90 NGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH 154

  Fly   278 GYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAF 342
            |||:||:||||||||..::|||||||||||:.:.||||||.||||.|..||.||||.|.||||||
Mouse   155 GYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAF 219

  Fly   343 QPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDAD 407
            ||||||||.:||:||||||||:||||||:.||.|||||||||:|.||||||.:..|.   :....
Mouse   220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC---DCGPP 281

  Fly   408 FANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKG--DKYRNSTVIPYLEAYH- 469
            .::|:.|||:.:|:||.|:::||..:|||.........:||||...  |::|:.||:||||..|
Mouse   282 LSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHG 346

  Fly   470 --YGTQEEDVYFTEHDV--NQELARQAAAAASEIRAKQSAAAL--AACHTYEPPSTSAAAASNSL 528
              ...:|||::..|..:  .|:..........|:.....:.:|  |.|.....|..|:
Mouse   347 RAEEEEEEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSS------- 404

  Fly   529 GNGSREEAPVKKKGSALKRRAKKLTSCISVRKLSHCR 565
                 :..|..:.|:|  ..|:|:.|...:|:||.|:
Mouse   405 -----KVKPEGRPGTA--NPARKVCSSNKIRRLSACK 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	178/262 (68%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	174/256 (68%)
Stk11	NP_035622.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000250	45..90		33/44 (75%)
		S_TKc	49..309	CDD:214567	178/262 (68%)
		STKc_LKB1	55..309	CDD:271021	174/256 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..421		6/37 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849513
Domainoid	1	1.000	372	1.000	Domainoid score	I895
eggNOG	1	0.900	-	-		E33208_3BA8D
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1684
Isobase	1	0.950	-	0	Normalized mean entropy	S2228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D856506at2759
OrthoFinder	1	1.000	-	-		FOG0006218
OrthoInspector	1	1.000	-	-		oto93666
orthoMCL	1	0.900	-	-		OOG6_104622
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2709
SonicParanoid	1	1.000	-	-		X5157
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.640