Protein Alignment Lkb1 and Stk11

DIOPT Version :10

• Sequence 1: NP_650302.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_035622.1
• Gene: Stk11 / 20869
• MGIID: 1341870
• Length: 436
• Species: Mus musculus
• Alignment Length: 427
• Identity: 226/427 - (52%)
• Similarity: 296/427 - (69%)
• Gaps: 26/427 - (6%)

  Fly   148 FFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIP 212
            |.:|:||.::|||.::|..|::|||:|||:|||||||||||.::||.|||.|||||.|:||||||
Mouse    25 FIHRIDSTEVIYQPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIP 89

  Fly   213 NGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAH 277
            |||.||.:||.||::|:||:|::||||||||||||||:||||||.|:|||:|..|:||.|:.|||
Mouse    90 NGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAH 154

  Fly   278 GYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAF 342
            |||:||:||||||||..::|||||||||||:.:.||||||.||||.|..||.||||.|.||||||
Mouse   155 GYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAF 219

  Fly   343 QPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDAD 407
            ||||||||.:||:||||||||:||||||:.||.|||||||||:|.||||||.:..|.   :....
Mouse   220 QPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPC---DCGPP 281

  Fly   408 FANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKG--DKYRNSTVIPYLEAYH- 469
            .::|:.|||:.:|:||.|:::||..:|||.........:||||...  |::|:.||:||||..|
Mouse   282 LSDLLRGMLEYEPAKRFSIRQIRQHSWFRKKHPLAEALVPIPPSPDTKDRWRSMTVVPYLEDLHG 346

  Fly   470 --YGTQEEDVYFTEHDV--NQELARQAAAAASEIRAKQSAAAL--AACHTYEPPSTSAAAASNSL 528
              ...:|||::..|..:  .|:..........|:.....:.:|  |.|.....|..|:
Mouse   347 RAEEEEEEDLFDIEDGIIYTQDFTVPGQVLEEEVGQNGQSHSLPKAVCVNGTEPQLSS------- 404

  Fly   529 GNGSREEAPVKKKGSALKRRAKKLTSCISVRKLSHCR 565
                 :..|..:.|:|  ..|:|:.|...:|:||.|:
Mouse   405 -----KVKPEGRPGTA--NPARKVCSSNKIRRLSACK 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_650302.1	STKc_LKB1	178..435	CDD:271021	174/256 (68%)
Stk11	NP_035622.1	Sufficient for interaction with SIRT1. /evidence=ECO:0000250	45..90		33/44 (75%)
		STKc_LKB1	55..309	CDD:271021	174/256 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	398..421		6/36 (17%)