DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and aak-2

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_510710.2	Gene:	aak-2 / 181727	WormBaseID:	WBGene00020142	Length:	626	Species:	Caenorhabditis elegans

Alignment Length:	355	Identity:	107/355 - (30%)
Similarity:	183/355 - (51%)	Gaps:	21/355 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ETLDRVTLDMGNMFFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLA 199
            |..||.:.|..:...:.........||:.|:...:|.||:.:.||.|::||||..::.....::|
Worm    50 ERKDRDSTDNSSKMSSPGGETSTKQQQELKAQIKIGHYILKETLGVGTFGKVKVGIHETTQYKVA 114

  Fly   200 VKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMID 264
            ||||.::|::.: :....:.|||..|...:|.|::.|..|:  .....::::||:..||  |:.|
Worm   115 VKILNRQKIKSL-DVVGKIRREIQNLSLFRHPHIIRLYQVI--STPSDIFMIMEHVSGG--ELFD 174

  Fly   265 Y-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFA 328
            | ....|:...:|..:|:|::.|::|.|...|:|:|:||.||||.....:||:|||::   ::..
Worm   175 YIVKHGRLKTAEARRFFQQIISGVDYCHRHMVVHRDLKPENLLLDEQNNVKIADFGLS---NIMT 236

  Fly   329 PDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRG 393
            ..|...|..|||.:..||:.:| :.:||.:||:||.||.||.|..|..||:.:::..|...|..|
Worm   237 DGDFLRTSCGSPNYAAPEVISG-KLYAGPEVDVWSCGVILYALLCGTLPFDDEHVPSLFRKIKSG 300

  Fly   394 QWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTWFRSAPVKTGPPIPIPPLKGDKYRN 458
            .:..|.:|   :....||:..||..||.||.:::::....||:    |..|....||:.    .:
Worm   301 VFPTPDFL---ERPIVNLLHHMLCVDPMKRATIKDVIAHEWFQ----KDLPNYLFPPIN----ES 354

  Fly   459 STVIPYLEAYHYGTQEEDVYFTEHDVNQEL 488
            ...|..:||....|:.:..:..|.:|...|
Worm   355 EASIVDIEAVREVTEFQRYHVAEEEVTSAL 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	86/263 (33%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	84/257 (33%)
aak-2	NP_510710.2	STKc_AMPK_alpha	84..339	CDD:270981	87/266 (33%)
		S_TKc	87..339	CDD:214567	86/263 (33%)
		UBA_AID_AMPKalpha	356..419	CDD:270521	7/29 (24%)
		AMPKA_C	462..624	CDD:213378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910