Protein Alignment Lkb1 and par-4

DIOPT Version :9

• Sequence 1: NP_001163606.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: NP_001366977.1
• Gene: par-4 / 180185
• WormBaseID: WBGene00003919
• Length: 617
• Species: Caenorhabditis elegans
• Alignment Length: 621
• Identity: 199/621 - (32%)
• Similarity: 299/621 - (48%)
• Gaps: 130/621 - (20%)

  Fly    49 TGGGAQHKV------EEEEP-----DPVEDEMTVLLANKNFHYDVASDLDDDAFVELKEDTA--- 99
            |..|||.|:      |.:|.     ||...:...:..|.:..||  .|.|||.|::..|.:|
 Worm     6 TSSGAQSKLLMPGDDEADEDHQNRGDPNLQQKQKIQLNVDPDYD--DDEDDDCFIDGCEASAPIT 68

  Fly   100 ----------QADDAGA--GVGFYNPDELLLDDQPHPQVTWLDDDEIETLD-------------- 138
                      ::.|...  .:|.|  ||  .||.        ||||.||.:
 Worm    69 RELVDGAIERRSKDRNVKMSIGVY--DE--YDDD--------DDDEEETEEDQRRRFVEGIRNIR 121

  Fly   139 ---RVTLDM---------------------GNMFFNRVDS--QDIIYQQ--KKKSIKMVGKYIMG 175
               :.:.|:                     ..|.||:.:|  |.|.::.  |:|..|::..|:.|
 Worm   122 HKQQESFDLEEHPIPVESEAMRQFINQQVNNAMMFNQDNSEFQHIEFEPIVKQKGPKIIEGYMWG 186

  Fly   176 DVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHVVELVDVL 240
            ..:|.||||||||.::...|.|.||||:...|||:|.||.:|:..|:::|:::.||:|::|:::.
 Worm   187 GQIGTGSYGKVKECIDMYTLTRRAVKIMKYDKLRKITNGWENIRSEMSILRRMNHRNVIKLIEIF 251

  Fly   241 YNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKPGNL 305
            ....|.|:|:|.|||:|.:|:::|.:|.:|:.:.::|..|.:|..||.||||.||.|||||||||
 Worm   252 NIPAKGKVYMVFEYCIGSVQQLLDMEPARRLTIGESHAIFIELCQGLNYLHSKRVSHKDIKPGNL 316

  Fly   306 LLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPE-IANGHETFAGFKVDIWSSGVTLY 369
            |:|:|.|:||.|||||||::||..|..||...|:|.||||| |...|:.|.|:|.|:||:|||||
 Worm   317 LVSIDFTVKICDFGVAEQINLFQRDGRCTKVNGTPKFQPPECIYGNHDFFDGYKADMWSAGVTLY 381

  Fly   370 NLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRHDTW 434
            ||.:|:||||...:.:|.|.||....:.|..: ::..|..:|:..:|:.|.::|.:..|.....|
 Worm   382 NLVSGKYPFEKPVLLKLYECIGTEPLQMPTNV-QLTKDLQDLLTKLLEKDFNERPTCLETMIHPW 445

  Fly   435 FRSA-PVKTGPPIPIPPLK-GDKYRNSTVIPYLEAYHYGTQEEDVYFTEHDVN--QE-------- 487
            |.|. |...|....:..:: ||  |..|::..:.|.:.|...||....|.::.  |:
 Worm   446 FLSTFPEDQGLGRIMERMRTGD--RPLTMLSSMTALYDGITPEDELIIEDNLGIIQQILPINLTS 508

  Fly   488 ---LARQAAAAASEIRAK------------QSAAALA--------ACHTYEPPSTSAAAASNSLG 529
               |.|.:......:.||            .|||.|.        :..|..||..:|..|.||..
 Worm   509 EAVLERGSFPGFKFLEAKPGDGPDGVEGSEDSAAPLGPQRRPSSRSMPTCAPPGPAAGNAQNSTA 573

  Fly   530 -NGSREEA--------PVKKKGSALKRRAKKLTSCI 556
             ||:..:.        |....|:..:||.:...|||
 Worm   574 ENGAETDGVASASDPPPTAAPGAPPRRRKRNFFSCI 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	118/263 (45%)
		STKc_LKB1	178..435	CDD:271021	116/257 (45%)
par-4	NP_001366977.1	PKc_like	189..446	CDD:419665	116/257 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166723
Domainoid	1	1.000	242	1.000	Domainoid score	I1242
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	255	1.000	Inparanoid score	I1959
Isobase	1	0.950	-	0	Normalized mean entropy	S2228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D517525at33208
OrthoFinder	1	1.000	-	-		FOG0006218
OrthoInspector	1	1.000	-	-		oto18201
orthoMCL	1	0.900	-	-		OOG6_104622
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2709
SonicParanoid	1	1.000	-	-		X5157
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.780