DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and Mark3

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_006515574.1	Gene:	Mark3 / 17169	MGIID:	1341865	Length:	806	Species:	Mus musculus

Alignment Length:	426	Identity:	119/426 - (27%)
Similarity:	203/426 - (47%)	Gaps:	64/426 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.|.:...:|:|::.|||.|.:......:|:||:.|.:|.  |...|.:.||:.::|.|.|.::
Mouse    53 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN--PTSLQKLFREVRIMKILNHPNI 115

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |.::.:||:|||..||  |:.|| ....||...:|...|:|:|..::|.|..|::|
Mouse   116 VKLFEVI--ETEKTLYLIMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKRIVH 176

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDT-CTTGQGSPAFQPPEIANGHETFAGFKVDI 361
            :|:|..||||..|..:||:|||.:.:..:.:..|| |    |||.:..||:..| :.:.|.:||:
Mouse   177 RDLKAENLLLDADMNIKIADFGFSNEFTVGSKLDTFC----GSPPYAAPELFQG-KKYDGPEVDV 236

  Fly   362 WSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSL 426
            ||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|..||:...|..:|.||.:|
Mouse   237 WSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP---FYMSTDCENLLKRFLVLNPVKRGTL 298

  Fly   427 QEIRHDTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEEDVY------------F 479
            ::|..|.|..:.                 :....:.|::|      .|.|:.            :
Mouse   299 EQIMKDRWINAG-----------------HEEDELKPFVE------PELDISDQKRIDIMVGMGY 340

  Fly   480 TEHDVNQELARQA--AAAASEIRAKQSAAALAACHTYEPPSTSAAAA------SNSLGNGSREEA 536
            ::.::.:.|::..  ...|:.:...:.:|.|.|..:....:.|.|..      |||.|.....:.
Mouse   341 SQEEIQESLSKMKYDEITATYLLLGRKSAELDASDSSSSSNLSLAKVRPNSDLSNSTGQSPHHKG 405

  Fly   537 PVKKKGSALKRR-----AKKLTSCISVRKLSHCRTS 567
            ......|..:||     ...:.|.::..|.|...|:
Mouse   406 QRSVSSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTA 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	95/264 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	94/258 (36%)
Mark3	XP_006515574.1	STKc_MARK	55..307	CDD:270974	95/265 (36%)
		UBA_MARK3_4	325..367	CDD:270590	3/41 (7%)
		MARK1-3_C	707..804	CDD:213381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910