DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and SIK1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_775490.2	Gene:	SIK1 / 150094	HGNCID:	11142	Length:	783	Species:	Homo sapiens

Alignment Length:	289	Identity:	95/289 - (32%)
Similarity:	159/289 - (55%)	Gaps:	15/289 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            |.::|.:: ||.|.:...||:|::..||.|.:.....::|:||:.|.:|.  .:..:.:.||:.|
Human    16 QGQQKPLR-VGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTRLD--SSNLEKIYREVQL 77

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLE 288
            :|.|.|.|:::|..|:  |.|..:|:|.|:...|  ||.|| ..:..:...:|...|.|::..:|
Human    78 MKLLNHPHIIKLYQVM--ETKDMLYIVTEFAKNG--EMFDYLTSNGHLSENEARKKFWQILSAVE 138

  Fly   289 YLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHET 353
            |.|...::|:|:|..||||..:..:|::|||..   :.:...:..:|..|||.:..||:..|.|
Human   139 YCHDHHIVHRDLKTENLLLDGNMDIKLADFGFG---NFYKSGEPLSTWCGSPPYAAPEVFEGKE- 199

  Fly   354 FAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQA 418
            :.|.::||||.||.||.|..|..||:|.|:..|.:.:..|::..|   :.|..|..:||..||..
Human   200 YEGPQLDIWSLGVVLYVLVCGSLPFDGPNLPTLRQRVLEGRFRIP---FFMSQDCESLIRRMLVV 261

  Fly   419 DPSKRLSLQEIRHDTWFRSAPVKTGPPIP 447
            ||::|:::.:||...|.|:.|...||..|
Human   262 DPARRITIAQIRQHRWMRAEPCLPGPACP 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	85/263 (32%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	84/257 (33%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	85/264 (32%)
		S_TKc	27..278	CDD:214567	85/263 (32%)
		UBA_SIK1	300..349	CDD:270591
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..377
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..477
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305\|PubMed:29211348	583..612
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	619..643
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910