DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and AgaP_AGAP002686

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_312237.4	Gene:	AgaP_AGAP002686 / 1273276	VectorBaseID:	AGAP002686	Length:	565	Species:	Anopheles gambiae

Alignment Length:	381	Identity:	116/381 - (30%)
Similarity:	196/381 - (51%)	Gaps:	42/381 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.||:|..||.||:||||...:.....::|||||.::|::.: :....:.|||..||..:|.|:
Mosquito    18 IGHYILGATLGTGSFGKVKIGEHQVTKHKVAVKILNRQKIKSL-DVVGKIRREIQNLKLFRHPHI 81

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            ::|..|:  .....::::|||..||  |:.|| ..:.::...:|..:|:|::.|::|.|...::|
Mosquito    82 IKLYQVI--STPTDIFMIMEYVSGG--ELFDYIVKNGKLQESEARRFFQQIISGVDYCHRHMIVH 142

  Fly   298 KDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAGFKVDIW 362
            :|:||.||||..::.:||:|||::   ::....:...|..|||.:..||:.:| :.:||.:||||
Mosquito   143 RDLKPENLLLDHNRHVKIADFGLS---NMMLDGEFLRTSCGSPNYAAPEVISG-KLYAGPEVDIW 203

  Fly   363 SSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQ 427
            |.||.||.|..|..||:.:::..|...|..|.:..|.:|   :....:|:..|||.||.||.:::
Mosquito   204 SCGVILYALLCGTLPFDDEHVPTLFRKIKSGVFPIPEYL---NKQVVSLLCQMLQVDPLKRATVE 265

  Fly   428 EIRHDTWFRSAPVKTGPPIPIP-PLKGDKYRNSTVIPYLEAYHYGTQEEDVYFT-----EHDV-- 484
            ||:...||:    |..|....| |::.|.....|.........:..:|.:|:..     .||.
Mosquito   266 EIKKHEWFQ----KDLPAYLFPSPVEQDSSVVDTNAIREVCEKFSVKEHEVHNALLSGDPHDQLA 326

  Fly   485 --------NQELARQAAAAASEIRAKQSAAALAACHTYEPPSTSAAAASNSLGNGS 532
                    |:.:|.:||.|  |::....|.:       .||..:.:.....||.||
Mosquito   327 IAYHLIIDNKRIADEAAKA--ELKEFYVAGS-------PPPPGADSKFGTPLGPGS 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	90/263 (34%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	87/257 (34%)
AgaP_AGAP002686	XP_312237.4	STKc_AMPK_alpha	18..273	CDD:270981	91/266 (34%)
		S_TKc	21..273	CDD:214567	90/263 (34%)
		UBA_AID_AMPKalpha	290..354	CDD:270521	11/65 (17%)
		AMPKA_C	436..563	CDD:213378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910