Protein Alignment Lkb1 and CAMKK2

DIOPT Version :9

• Sequence 1: NP_001163606.1
• Gene: Lkb1 / 41673
• FlyBaseID: FBgn0038167
• Length: 567
• Species: Drosophila melanogaster
• Sequence 2: XP_016874183.1
• Gene: CAMKK2 / 10645
• HGNCID: 1470
• Length: 606
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 167/658 - (25%)
• Similarity: 263/658 - (39%)
• Gaps: 203/658 - (30%)

  Fly     3 CSSSRPVGGKAAGGAEAGGAGATGQMTVTTMEAQVKAAHHHHLHHPTGGGAQHKVEEEEPDPVE- 66
            |.||:|...:||...|.||.|::                                ..|...|.|
Human     4 CVSSQPSSNRAAPQDELGGRGSS--------------------------------SSESQKPCEA 36

  Fly    67 ----DEMTVLLANKNFHYDVASDLDDDAFVEL---KEDTAQADDAGAGVGFYNPDELLLDD---- 120
                ..:::.|..::|  .|.::.:....|:|   ::...:||.          .|:.||.
Human    37 LRGLSSLSIHLGMESF--IVVTECEPGCAVDLGLARDRPLEADG----------QEVPLDTSGSQ 89

  Fly   121 -QPHPQVTWLDDDEIETLDRV--------TLDMG------NMFFNRVDS---------------- 154
             :||     |...::...:|.        :|||.      ::.::.|.|
Human    90 ARPH-----LSGRKLSLQERSQGGLAAGGSLDMNGRCICPSLPYSPVSSPQSSPRLPRRPTVESH 149

  Fly   155 -------QDIIYQQKKKSIK-MVGKYIMGDVL----------GEGSYGKVKEAMNSENLCRLAVK 201
                   ||.: |..:.::| .:|| :||.::          .:||||.||.|.|..:....|:|
Human   150 HVSITGMQDCV-QLNQYTLKDEIGK-LMGGIITMVKTPNASRKQGSYGVVKLAYNENDNTYYAMK 212

  Fly   202 ILTKRKL---------------RRIPNG--------EQNVTREIALLKQLKHRHVVELVDVLYNE 243
            :|:|:||               |..|.|        || |.:|||:||:|.|.:||:||:||.:.
Human   213 VLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQ-VYQEIAILKKLDHPNVVKLVEVLDDP 276

  Fly   244 EKQKMYLVMEYCVGGLQEMIDYQPDKRMPLF------QAHGYFKQLVDGLEYLHSCRVIHKDIKP 302
            .:..:|:|.        |:::..|...:|..      ||..||:.|:.|:||||..::||:||||
Human   277 NEDHLYMVF--------ELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKP 333

  Fly   303 GNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPE-IANGHETFAGFKVDIWSSGV 366
            .|||:..|..:||:||||:.:..  ..|...:...|:|||..|| ::...:.|:|..:|:|:.||
Human   334 SNLLVGEDGHIKIADFGVSNEFK--GSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGV 396

  Fly   367 TLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRH 431
            |||....||.||..:.|..|...|.....|.|. ..::..|..:||..||..:|..|:.:.||:.
Human   397 TLYCFVFGQCPFMDERIMCLHSKIKSQALEFPD-QPDIAEDLKDLITRMLDKNPESRIVVPEIKL 460

  Fly   432 DTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEEDVYFTEHDVNQELARQAAAAA 496
            ..|     |......|:|    .:..|.|::..       |:||    .|:.|     :...:.|
Human   461 HPW-----VTRHGAEPLP----SEDENCTLVEV-------TEEE----VENSV-----KHIPSLA 500

  Fly   497 SEIRAKQSAAALAACHTYEPPSTSAAAASNSLGN---GS-REEAPVKKKGSALKRRAKKLTSCIS 557
            :.|..|                  ......|.||   || |||..:...|:.|.:  |....|.|
Human   501 TVILVK------------------TMIRKRSFGNPFEGSRREERSLSAPGNLLTK--KPTRECES 545

  Fly   558 VRKLSHCR 565
            :.:|...|
Human   546 LSELKEAR 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	100/302 (33%)
		STKc_LKB1	178..435	CDD:271021	98/296 (33%)
CAMKK2	XP_016874183.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D856506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920