DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and LOC100495980

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_017952054.2	Gene:	LOC100495980 / 100495980	-ID:	-	Length:	737	Species:	Xenopus tropicalis

Alignment Length:	358	Identity:	69/358 - (19%)
Similarity:	123/358 - (34%)	Gaps:	125/358 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LHHPTGGGAQHK----------VEEEEPDPVEDEMTVLLAN---KNFH----------------Y 80
            |.|..||...:|          |...|.|..:..|..||.:   ||..                |
Frog   364 LGHSAGGCRTYKDTFWTNPQFLVTLTEQDEEKHGMCTLLVSLMQKNRRQCRSIGQDFLSVGFEIY 428

  Fly    81 DVASDLDDDAFVELKEDTAQADDAGAGVGFYN-----------PDELLL---DDQPH-------- 123
            .|..:.|:......:::...:..:.|...|.:           |...||   ..|||
Frog   429 QVPKEFDNKMCASERKNLFSSLVSVASCSFMDERDVTGRYQLPPGRYLLIPSTFQPHQESDFIMR 493

  Fly   124 ----PQVTWLD-DDEIETLDRVTLDMGNMFFNRVDSQDIIYQQKKKSIKMVGKYIMGDVLGEGS- 182
                .|.|::: |.||..       .||:|             |:.::|        |.:.|.|
Frog   494 IFTEKQHTFIEIDCEIRA-------NGNVF-------------KENALK--------DTMEEFSA 530

  Fly   183 -YGKVK---EAMNSENLCRLAVKILTK--------------RKLRRIP----NGEQNVTREIALL 225
             :.::.   :.::.|.|.|:.::|.:|              |||.::.    ||:..:.....|.
Frog   531 QFARLSGEDQEISPEELQRILIQITSKNTHLKTNGFSLDICRKLVKMVDLNCNGKLQLEEFRKLW 595

  Fly   226 KQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRM--PLFQAHG------YFKQ 282
            .::|.   .|.:...|::::.....|.|.|:.  .|...:..:.::  .|.|.:|      ||..
Frog   596 SKIKE---WEKIFTNYDKDRSGTMDVQELCLA--LEAAGFTLNNQLVESLCQKYGNNVRQVYFDS 655

  Fly   283 LVDGLEYL----HSCRVIHKDIKPGNLLLSLDQ 311
            .:..|.||    ..||::.|: |.|.:.:|.::
Frog   656 FLSCLAYLVCVFEQCRIMDKN-KDGVICISKEE 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	35/175 (20%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	34/169 (20%)
LOC100495980	XP_017952054.2	Peptidase_C2	44..340	CDD:395523
		Calpain_III	361..495	CDD:395848	24/130 (18%)
		EFh_PEF	527..687	CDD:355382	34/165 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165176980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930