DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and camkk1b

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_021337000.1	Gene:	camkk1b / 100170786	ZFINID:	ZDB-GENE-080722-13	Length:	484	Species:	Danio rerio

Alignment Length:	513	Identity:	149/513 - (29%)
Similarity:	230/513 - (44%)	Gaps:	104/513 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DVAS--DLDDDAFVELKEDTAQADDAGAGV----GF-YNPDELLLDDQPHPQVTWLDDDEIETLD 138
            |.||  |||.|...||.:..|....|...:    |: ..|..|.|.|:           ::...:
Zfish     4 DTASRLDLDSDYHAELADMVAAMSVAATRLTPPNGYRTTPHRLNLSDR-----------KLSLQE 57

  Fly   139 RVTLDMGNMFFNRVDSQDIIYQQKKKSIK------MVGKYIMGDVLGEGSYGKVKEAMNSENLCR 197
            |.:...|.   .|:..:..| :.|:.||.      .:.:|.:.:.:|:||||.||.|.|.::...
Zfish    58 RSSCQNGG---PRMARRPTI-ESKRVSISDGDDCVQLNQYKLKNEIGKGSYGVVKLAYNEDDDQY 118

  Fly   198 LAVKILTKRKL-------RRIPNGEQN------------------VTREIALLKQLKHRHVVELV 237
            .|:|:::|::|       ||.|:.|.|                  |.:|||:||:|.|.:||:||
Zfish   119 YAMKLVSKKRLIKQLGFRRRPPSRESNGSVGSQENLLKPSGLLDRVYQEIAILKKLDHLNVVKLV 183

  Fly   238 DVLYNEEKQKMYLVMEYCVGGLQEMIDYQPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIHKDIKP 302
            :||.:..:..:::|.|....|  .:::...|..:....||.||:.::.|:||||..::||:||||
Zfish   184 EVLDDPAEDNLHMVFELVPKG--PVMEVPTDSPLSEEMAHLYFRDIILGIEYLHYQKIIHRDIKP 246

  Fly   303 GNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPE-IANGHETFAGFKVDIWSSGV 366
            .||||..|..:||:||||:.:.:  ..|...:...|:|||..|| :.:..:.|:|..:|||:.||
Zfish   247 SNLLLGDDGHVKIADFGVSNEFE--GNDALLSNSAGTPAFMAPETLTDQDQRFSGKALDIWAMGV 309

  Fly   367 TLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPSKRLSLQEIRH 431
            ||:....|:.||..|.|..|.|.|.....|.|. ..|:.....:||..||...|..|::|.||:.
Zfish   310 TLFCFVFGKCPFHDDYILGLHEKIRSMSVEFPD-KPEISEQLKDLITRMLDKVPETRITLAEIKL 373

  Fly   432 DTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAYHYGTQEEDVYFTEHDVNQELARQAAAAA 496
            ..|.      |.....:.||:.|   :.||               |..||.:| |...:...:.:
Zfish   374 HPWV------TVDGTDLLPLEED---HCTV---------------VEVTEEEV-QNSVKLVPSLS 413

  Fly   497 SEIRAKQSAAALAACHTYEPP------STSA--------------AAASNSLGNGSRE 534
            :.|..|......:..:.:|.|      |.||              :..|||..|||||
Zfish   414 AVILVKSMLRKRSFSNPFECPSGRQGRSMSAPGGLTVDMSLFRPLSRGSNSNSNGSRE 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	99/288 (34%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	98/282 (35%)
camkk1b	XP_021337000.1	STKc_CAMKK	98..378	CDD:271020	99/290 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910