DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and mark2b

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	XP_009301419.1	Gene:	mark2b / 100005996	ZFINID:	ZDB-GENE-080215-4	Length:	790	Species:	Danio rerio

Alignment Length:	446	Identity:	127/446 - (28%)
Similarity:	200/446 - (44%)	Gaps:	91/446 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 VGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIALLKQLKHRHV 233
            :|.|.:...:|:|::.|||.|.:......:||||:.|.:|.  .:..|.|.||:.::|.|.|.::
Zfish    46 IGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKIIDKTQLN--SSSLQKVFREVRIMKLLNHPNI 108

  Fly   234 VELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-QPDKRMPLFQAHGYFKQLVDGLEYLHSCRVIH 297
            |:|.:|:  |..:.:||||||..||  |:.|| ....||...:|...|:|:|..::|.|...::|
Zfish   109 VKLFEVI--ETDKTLYLVMEYASGG--EVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVH 169

  Fly   298 KDIKPGNLLLSLDQTLKISDFG------VAEQLDLFAPDDTCTTGQGSPAFQPPEIANGHETFAG 356
            :|:|..||||..|..:||:|||      |..:||.|.         |||.:..||:..| :.:.|
Zfish   170 RDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFC---------GSPPYAAPELFQG-KKYDG 224

  Fly   357 FKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILGMLQADPS 421
            .:||:||.||.||.|.:|..||:|.|:..|.|.:.||::..|   :.|..|..||:...|..:|:
Zfish   225 PEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP---FYMSTDCENLLKKFLILNPT 286

  Fly   422 KRLSL-QEIRHDTWFRSAPVKTGPPIPIPPLKGDKYRNSTVIPYLEAY--HYGTQEEDVY----F 479
            ||.|| |:|..|.|....                 |.:..:.||:|..  :...:..|:.    |
Zfish   287 KRGSLEQQIMKDRWMNVG-----------------YEDDDLKPYIEPQPDYKDPRRTDIMLQMGF 334

  Fly   480 TEHDVNQELARQAAAAASEIRA---------------------KQSAAALAACHTYEPP------ 517
            ::.::...|.:|   ..:|:.|                     .:..:.|...:...||
Zfish   335 SQEEIEDSLVKQ---KYNEVMATYLLLDYRNSELDEGVNLSLKSRPGSDLTNSNAPSPPHKVQRS 396

  Fly   518 -STSAAAASNSLGNGSREEAP----------VKKKGSALKRRAKKLTSCISVRKLS 562
             |::...|..|...||..:.|          ..:|||:...:........|.||.|
Zfish   397 VSSTQKPARRSTDQGSYSKRPQGENKHGVEDSGRKGSSSSTKVPPSPVISSERKKS 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	99/270 (37%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	98/264 (37%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	99/271 (37%)
		S_TKc	49..301	CDD:214567	99/270 (37%)
		UBA_MARK2	319..360	CDD:270589	6/43 (14%)
		AMPKA_C_like	691..789	CDD:302605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910