DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lkb1 and prkaa1

DIOPT Version :9

Sequence 1:	NP_001163606.1	Gene:	Lkb1 / 41673	FlyBaseID:	FBgn0038167	Length:	567	Species:	Drosophila melanogaster
Sequence 2:	NP_001103756.1	Gene:	prkaa1 / 100001198	ZFINID:	ZDB-GENE-030325-1	Length:	573	Species:	Danio rerio

Alignment Length:	282	Identity:	101/282 - (35%)
Similarity:	164/282 - (58%)	Gaps:	21/282 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QQKKKSIKMVGKYIMGDVLGEGSYGKVKEAMNSENLCRLAVKILTKRKLRRIPNGEQNVTREIAL 224
            :||.:....:|.||:||.||.|::||||...:.....::|||||.::|:|.: :....:.|||..
Zfish     5 KQKHEGRVKIGHYILGDTLGVGTFGKVKVGQHELTKHQVAVKILNRQKIRSL-DVVGKIRREIQN 68

  Fly   225 LKQLKHRHVVELVDVLYNEEKQKMYLVMEYCVGGLQEMIDY-----QPDKRMPLFQAHGYFKQLV 284
            ||..:|.|:::|..|:  .....:::||||..||  |:.||     :.|::    ::...|:|::
Zfish    69 LKLFRHPHIIKLYQVI--STPTDIFMVMEYVSGG--ELFDYICKNGKLDEK----ESRRLFQQII 125

  Fly   285 DGLEYLHSCRVIHKDIKPGNLLLSLDQTLKISDFGVAEQLDLFAPDDTCTTGQGSPAFQPPEIAN 349
            .|::|.|...|:|:|:||.|:||......||:|||::   ::.:..:...|..|||.:..||:.:
Zfish   126 SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLS---NMMSDGEFLRTSCGSPNYAAPEVIS 187

  Fly   350 GHETFAGFKVDIWSSGVTLYNLATGQYPFEGDNIYRLLENIGRGQWEAPAWLYEMDADFANLILG 414
            | ..:||.:||||||||.||.|..|..||:.|::..|.:.|..|.:..|.:|   :....:|:..
Zfish   188 G-RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFFTPQYL---NPSVISLLKH 248

  Fly   415 MLQADPSKRLSLQEIRHDTWFR 436
            |||.||.||.:::|||.|.||:
Zfish   249 MLQVDPMKRATIKEIREDEWFK 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lkb1	NP_001163606.1	S_TKc	172..435	CDD:214567	96/267 (36%)
Lkb1	NP_001163606.1	STKc_LKB1	178..435	CDD:271021	92/261 (35%)
prkaa1	NP_001103756.1	STKc_AMPK_alpha	14..269	CDD:270981	97/270 (36%)
		S_TKc	17..269	CDD:214567	96/267 (36%)
		UBA_AID_AAPK1	286..350	CDD:270586
		AMPKA1_C	398..571	CDD:213384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910