DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and HTRA3

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_444272.1	Gene:	HTRA3 / 94031	HGNCID:	30406	Length:	453	Species:	Homo sapiens

Alignment Length:	199	Identity:	43/199 - (21%)
Similarity:	77/199 - (38%)	Gaps:	53/199 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RNGQILAAND------------NVGMS-GPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELM 78
            |.|:.|...|            |.|.| ||||:.:|   ..|.:..:::.......:.:|
Human   279 REGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDG---EVIGINTLKVTAGISFAIPSD----- 335

  Fly    79 NQIQTLLNQYHSE-------------IATTDPELVNRASALDLDSDRSPGGANITDLAPARAIVV 130
             :|...|.::..:             :.|..|.||:...|.:.|......|            :.
Human   336 -RITRFLTEFQDKQIKDWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSG------------IY 387

  Fly   131 VNLVSPDSPAERAGLCAGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLI 195
            |..|:|:||::|.|:..||.|::.    :|....|.:::.|.|  :....:.|:|:||...|...
Human   388 VQEVAPNSPSQRGGIQDGDIIVKV----NGRPLVDSSELQEAV--LTESPLLLEVRRGNDDLLFS 446

  Fly   196 LVPK 199
            :.|:
Human   447 IAPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	16/69 (23%)
HTRA3	NP_444272.1	IGFBP	25..76	CDD:278641
		Kazal_2	81..126	CDD:284958
		Serine protease	175..340		15/69 (22%)
		Trypsin_2	175..319	CDD:290102	13/42 (31%)
		PDZ_serine_protease	355..440	CDD:238487	24/102 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900