DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and HTRA1

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_002766.1	Gene:	HTRA1 / 5654	HGNCID:	9476	Length:	480	Species:	Homo sapiens

Alignment Length:	174	Identity:	37/174 - (21%)
Similarity:	72/174 - (41%)	Gaps:	32/174 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NVGMS-GPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELMNQIQTLLNQYHSEIATTDPELV 100
            |.|.| ||||:.:|   ..|.:..:::.......:.:|      :|:..|.:.|...|.......
Human   324 NYGNSGGPLVNLDG---EVIGINTLKVTAGISFAIPSD------KIKKFLTESHDRQAKGKAITK 379

  Fly   101 NRASALDLDSDRSPGGANITD--------LAPARAIVVVNLVSPDSPAERAGLCAGDAILRFG-- 155
            .:...:.:.|..|.....:.|        ::.|..|.|:    ||:|||..||...|.|:...
Human   380 KKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVI----PDTPAEAGGLKENDVIISINGQ 440

  Fly   156 SINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVPK 199
            |:.|.|      .:.::::...:.|  :.|:||.:.:.:.::|:
Human   441 SVVSAN------DVSDVIKRESTLN--MVVRRGNEDIMITVIPE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	17/79 (22%)
HTRA1	NP_002766.1	IB	35..111	CDD:197525
		KAZAL	115..155	CDD:197624
		DegQ	154..480	CDD:223343	37/174 (21%)
		Serine protease	204..364		11/48 (23%)
		Trypsin_2	204..342	CDD:290102	9/20 (45%)
		PDZ_serine_protease	382..473	CDD:238487	22/102 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900