DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and htra1a

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001002219.1	Gene:	htra1a / 431766	ZFINID:	ZDB-GENE-040704-64	Length:	479	Species:	Danio rerio

Alignment Length:	183	Identity:	35/183 - (19%)
Similarity:	70/183 - (38%)	Gaps:	52/183 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 NVGMS-GPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELMNQIQTLLNQYHSEIA----TTD 96
            |.|.| ||||:.:|   ..|.:..:::.......:.:|      :|:..|.:.:..:|    ||.
Zfish   323 NYGNSGGPLVNLDG---EVIGINTLKVTAGISFAIPSD------KIRQFLAESYDRLARGRGTTK 378

  Fly    97 PELVNRASALDLDSDRSPGGANITDLAPA----------------RAIVVVNLVSPDSPAERAGL 145
            ...:               |..:..|.|:                ....|:.::| .:||...||
Zfish   379 KRYI---------------GVRMMTLTPSLSKELKGRLRDFPDITSGAYVIEVIS-KTPAAAGGL 427

  Fly   146 CAGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVP 198
            ...|.|:   ||| |........:..:::  :..::::.|:||.:.:.|.::|
Zfish   428 KEHDVII---SIN-GQRISTATDVSAIIK--KESSLRVVVRRGNEDIILTIIP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	15/85 (18%)
htra1a	NP_001002219.1	IGFBP	31..87	CDD:278641
		KAZAL_FS	111..153	CDD:238052
		DegQ	160..479	CDD:223343	35/183 (19%)
		Serine protease	203..363		11/48 (23%)
		Trypsin_2	203..341	CDD:290102	9/20 (45%)
		PDZ_serine_protease	380..472	CDD:238487	19/113 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900