DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and Htra3

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_001257956.1	Gene:	Htra3 / 360959	RGDID:	1308120	Length:	459	Species:	Rattus norvegicus

Alignment Length:	199	Identity:	45/199 - (22%)
Similarity:	79/199 - (39%)	Gaps:	53/199 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RNGQILAAND------------NVGMS-GPLVDAEGFPRNDIDVYQVRLARQTIICLQNDHKELM 78
            |:|:.|...|            |.|.| ||||:.:|   ..|.:..:::|......:.:|
  Rat   285 RDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDG---EVIGINTLKVAAGISFAIPSD----- 341

  Fly    79 NQIQTLLNQYHSE-------------IATTDPELVNRASALDLDSDRSPGGANITDLAPARAIVV 130
             :|...|:::..:             :.|..|.||......:.|......|            :.
  Rat   342 -RITRFLSEFQDKHVKDWKKRFIGIRMRTITPSLVEELKTANPDFPAVSSG------------IY 393

  Fly   131 VNLVSPDSPAERAGLCAGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLI 195
            |..|.|:||::|.|:..||.|::.    :|....|.:::.|.|.|..|  :.|:|:||...|...
  Rat   394 VQEVVPNSPSQRGGIQDGDIIVKV----NGRPLVDSSELQEAVLNESS--LLLEVRRGNDDLLFS 452

  Fly   196 LVPK 199
            ::|:
  Rat   453 IMPE 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	18/69 (26%)
Htra3	NP_001257956.1	IGFBP	31..82	CDD:278641
		Kazal_2	87..132	CDD:284958
		Serine protease. /evidence=ECO:0000250	181..346		16/69 (23%)
		Trypsin_2	181..325	CDD:290102	13/42 (31%)
		PDZ_serine_protease	361..446	CDD:238487	25/102 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900