DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and Htra4

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	XP_036010000.1	Gene:	Htra4 / 330723	MGIID:	3036260	Length:	499	Species:	Mus musculus

Alignment Length:	236	Identity:	54/236 - (22%)
Similarity:	79/236 - (33%)	Gaps:	88/236 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAAG-TTTKERLERLINAKK------QLEAQINRNGQILAANDNVGMSGPLVDAEGFPRNDIDVY 58
            :.|| .:|.:|..|.:..|.      |.:|.||        :.|.|  ||||:.:|      ||.
Mouse   312 VTAGIVSTTQRGGRELGLKNSDIDYIQTDAIIN--------HGNSG--GPLVNLDG------DVI 360

  Fly    59 QVRLARQTI---ICLQNDHKELMNQIQTLLNQYH---------------------------SEIA 93
            .:...:.|.   ..:.:|      :|:..|..||                           .|:.
Mouse   361 GINTLKVTAGISFAIPSD------RIRQFLEDYHERQLKGKAPLQKKYLGLRMLPLTLNLLQEMK 419

  Fly    94 TTDPELVNRASALDLDSDRSPGGANITDLAPARAIVVVNLVSPDSPAERAGLCAGDAILRFGSIN 158
            ..|||.          .|.|.|             |.|..|...|.|..:||...|.|:   |||
Mouse   420 RQDPEF----------PDVSSG-------------VFVYEVIQGSAAASSGLRDHDVIV---SIN 458

  Fly   159 SGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVPK 199
             |........:.|.|::  :..:.:.|.||.|.|.|.:.|:
Mouse   459 -GQPVTTTTDVIEAVKD--NDFLSIIVLRGSQTLFLTVTPE 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	15/69 (22%)
Htra4	XP_036010000.1	IGFBP	85..139	CDD:395164
		Kazal_2	156..204	CDD:400135
		degP_htrA_DO	222..>494	CDD:273938	53/232 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900