DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9588 and HTRA2

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_037379.1	Gene:	HTRA2 / 27429	HGNCID:	14348	Length:	458	Species:	Homo sapiens

Alignment Length:	183	Identity:	46/183 - (25%)
Similarity:	76/183 - (41%)	Gaps:	42/183 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 AANDNVGMSGPLVDAEGFPRNDIDVYQVRLARQTIICLQNDH-KELMNQIQTLLNQYHSEIATTD 96
            ||.|.....||||:.:|   ..|.|..:::.......:.:|. :|.:::
Human   299 AAIDFGNSGGPLVNLDG---EVIGVNTMKVTAGISFAIPSDRLREFLHR---------------- 344

  Fly    97 PELVNRASALDLDSDRSPGGANITDLAPA---------------RAIVVVNLVSPDSPAERAGLC 146
            .|..|.:|.:. .|.|...|..:..|:|:               :..|:::.|...|||.||||.
Human   345 GEKKNSSSGIS-GSQRRYIGVMMLTLSPSILAELQLREPSFPDVQHGVLIHKVILGSPAHRAGLR 408

  Fly   147 AGDAILRFGSINSGNFKGDLAQIGELVRNMQSQNVQLKVKRGEQQLDLILVPK 199
            .||.||..|.....|.:    .:.|.||. ||| :.::::||.:.|.|.:.|:
Human   409 PGDVILAIGEQMVQNAE----DVYEAVRT-QSQ-LAVQIRRGRETLTLYVTPE 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	24/84 (29%)
HTRA2	NP_037379.1	IAP-binding motif	134..137
		DegQ	150..>453	CDD:333159	45/179 (25%)
		Serine protease	166..342		12/45 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900