DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9588 and HTRA4

DIOPT Version :9

Sequence 1:	NP_650301.1	Gene:	CG9588 / 41672	FlyBaseID:	FBgn0038166	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_710159.1	Gene:	HTRA4 / 203100	HGNCID:	26909	Length:	476	Species:	Homo sapiens

Alignment Length:	212	Identity:	46/212 - (21%)
Similarity:	87/212 - (41%)	Gaps:	50/212 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TTKERLERLINAKK------QLEAQINRNGQILAANDNVGMSGPLVDAEGFPRNDIDVYQVRLAR 64
            :||:|..:.:..|.      |::|.||..        |.|  ||||:.:|   :.|.|..:|:..
Human   296 STKQRGGKELGMKDSDMDYVQIDATINYG--------NSG--GPLVNLDG---DVIGVNSLRVTD 347

  Fly    65 QTIICLQNDHKELMNQIQTLLNQYHSEIATTDPELVNRASA------LDLDSDRSPGGANI---- 119
            .....:.:|      :::..|.:||      :.::..:|.:      |.:.|...|....:
Human   348 GISFAIPSD------RVRQFLAEYH------EHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHY 400

  Fly   120 TDLAPARAIVVVNLVSPDSPAERAGLCAGDAILRFGSINSGNFKG-DLAQIGELVRNMQSQNVQL 183
            .|.....:.|.|..|...:.|:.:||...|.|:        |..| .:....::|:.:.|.::.:
Human   401 PDFPDVSSGVYVCKVVEGTAAQSSGLRDHDVIV--------NINGKPITTTTDVVKALDSDSLSM 457

  Fly   184 KVKRGEQQLDLILVPKT 200
            .|.||:..|.|.::|:|
Human   458 AVLRGKDNLLLTVIPET 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9588	NP_650301.1	PDZ	116..186	CDD:238080	13/74 (18%)
HTRA4	NP_710159.1	IGFBP	40..94	CDD:278641
		Kazal_2	108..152	CDD:284958
		DegQ	156..470	CDD:223343	44/206 (21%)
		Serine protease	202..362		19/84 (23%)
		Trypsin_2	202..340	CDD:290102	16/56 (29%)
		PDZ_serine_protease	380..470	CDD:238487	21/97 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0265
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900