Protein Alignment Task6 and KCNK6

DIOPT Version :10

• Sequence 1: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_004814.1
• Gene: KCNK6 / 9424
• HGNCID: 6281
• Length: 313
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 75/259 - (28%)
• Similarity: 125/259 - (48%)
• Gaps: 43/259 - (16%)

  Fly    18 YLLVGAAVFDALE--------SETEKRRWEALQ-------DAEDMIIRKYNISQEDFKVMETVVL 67
            ||::||.:...||        :|.|..|.:.||       .|.|..:.:...:..    :..|||
Human    17 YLVLGALLVARLEGPHEARLRAELETLRAQLLQRSPCVAAPALDAFVERVLAAGR----LGRVVL 77

  Fly    68 KSESHKAGQQ---WKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIG 129
            .:.|..|...   |.|..|.::|:|::||:|||::||.|..||.|::.:|::|:|..:::..:..
Human    78 ANASGSANASDPAWDFASALFFASTLITTVGYGYTTPLTDAGKAFSIAFALLGVPTTMLLLTASA 142

  Fly   130 ERVNRLSSYVIKAVRS--------SLRCKRTVASEVDLICVVTTLSSLTIAGGAAAFSKF-EGWS 185
            :|::.|.::|..:..|        ...|...||    |:.||.|:..|.   .|..|:.. |.||
Human   143 QRLSLLLTHVPLSWLSMRWGWDPRRAACWHLVA----LLGVVVTVCFLV---PAVIFAHLEEAWS 200

  Fly   186 YFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMF-ALIFILFGLAIVAASLNLLVLRFVT 248
            :.|:.|:|||:|:|||.||.|..:...    :|...:: .|:.:...|.:||..|.|...|.|:
Human   201 FLDAFYFCFISLSTIGLGDYVPGEAPG----QPYRALYKVLVTVYLFLGLVAMVLVLQTFRHVS 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	19/53 (36%)
		Ion_trans_2	165..243	CDD:462301	26/79 (33%)
KCNK6	NP_004814.1	Ion_trans_2	75..146	CDD:462301	25/70 (36%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		3/4 (75%)
		Ion_trans_2	180..256	CDD:462301	27/82 (33%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	282..290
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..313
		Lysosomal targeting signal. /evidence=ECO:0000250|UniProtKB:G3V8R8	308..312