Protein Alignment Task6 and KCNB2

DIOPT Version :10

• Sequence 1: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_004761.2
• Gene: KCNB2 / 9312
• HGNCID: 6232
• Length: 911
• Species: Homo sapiens
• Alignment Length: 426
• Identity: 83/426 - (19%)
• Similarity: 150/426 - (35%)
• Gaps: 149/426 - (34%)

  Fly    32 ETEKRRWEALQDAEDMIIRK-YNISQEDFKVMETVVLK-------SESHKAGQ------------ 76
            :..|:.|:.|:.....:..| ..|....|.|:.|:.|.       .|:.:.||
Human   174 DKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEA 238

  Fly    77 -------------------QWK-FTGAF----------YYATTVLTTIGYGHSTPSTVGGKLFTM 111
                               :|| |.|..          ||.|..||     .|..|
Human   239 VCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLT-----ESNKS--------- 289

  Fly   112 CYAIVGIPLGLVMFQSIGE-----RVNRLSSYVIKAVRSSLRCK------RTVASEVDLICVVTT 165
                      ::.||::..     |:.|:.. ::|..|.|...:      |...:|:.|:.
Human   290 ----------VLQFQNVRRVVQIFRIMRILR-ILKLARHSTGLQSLGFTLRRSYNELGLLI---- 339

  Fly   166 LSSLTIAGGAAAFS-------KFEGWSYFDSV----YYCFITLTTIGFGDMVALQRDNALNRKPE 219
               |.:|.|...||       |.|..:.|.|:    ::..||:||:|:||:.           |:
Human   340 ---LFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIY-----------PK 390

  Fly   220 YVMFALI---FILFGLAIVAASLNLLVLRFVTMNTEDERRDEA-QAMQALQVAVKLEGDVITSN- 279
            .::..::   ..:.|:.::|..:.::|..|.....|.:|:::| :..:||:.| |..|.:::.|
Human   391 TLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERA-KRNGSIVSMNL 454

  Fly   280 -GSILSGYEGHD------GQSLNGSNTSSMCSCHCICLNGNR----HKKSSNLEKNNDAENQY-K 332
             .:.....|..|      |:|.|..:::.  ..|   |:.:|    .|..|....|...||:| :
Human   455 KDAFARSMELIDVAVEKAGESANTKDSAD--DNH---LSPSRWKWARKALSETSSNKSFENKYQE 514

  Fly   333 LRQSPTHIRHLLPEVVPMQDLNYDYDTQSLHTLADR 368
            :.|..:|           :.||....:...|..|.:
Human   515 VSQKDSH-----------EQLNNTSSSSPQHLSAQK 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	13/69 (19%)
		Ion_trans_2	165..243	CDD:462301	19/91 (21%)
KCNB2	NP_004761.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		BTB_POZ_KCNB2	19..145	CDD:349719
		Ion_trans	192..428	CDD:459842	52/278 (19%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	381..386		2/4 (50%)
		Kv2channel	471..759	CDD:397541	18/85 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	503..534		8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..571
		FFAT. /evidence=ECO:0000269|PubMed:33124732	605..611
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	637..665
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..739
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	760..865
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	892..911