DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Task6 and KCNK17

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_113648.2	Gene:	KCNK17 / 89822	HGNCID:	14465	Length:	332	Species:	Homo sapiens

Alignment Length:	266	Identity:	79/266 - (29%)
Similarity:	133/266 - (50%)	Gaps:	43/266 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TISLIVCTFTYLLVGAAVFDALESET--------EKRRWEALQD-------AEDMIIRKYNISQE 57
            |:.|::....||.:|..||..||...        ::.:||.||:       |.|.:||  ::.|.
Human    22 TVLLLLAYLAYLALGTGVFWTLEGRAAQDSSRSFQRDKWELLQNFTCLDRPALDSLIR--DVVQA 84

  Fly    58 DFKVMETVVLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGL 122
             :|  ....|.|.:...| :|:..|:|:::.:.:||||||:.:|:|:..:||.:.:|:|||||.|
Human    85 -YK--NGASLLSNTTSMG-RWELVGSFFFSVSTITTIGYGNLSPNTMAARLFCIFFALVGIPLNL 145

  Fly   123 VMFQSIG----ERVNRLSSYVIKAVRSSLRCKRTVASEVDL--ICVVTTLSSLTIAGGAAAFSKF 181
            |:...:|    :.||..:|.:....:...:.:....|...|  :.:...|..|       .||..
Human   146 VVLNRLGHLMQQGVNHWASRLGGTWQDPDKARWLAGSGALLSGLLLFLLLPPL-------LFSHM 203

  Fly   182 EGWSYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMF----ALIFILFGLAIVAASLNLL 242
            |||||.:..|:.||||:|:||||.|.     .:|....|.::    ..::||||:|.:|..:.|:
Human   204 EGWSYTEGFYFAFITLSTVGFGDYVI-----GMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLI 263

  Fly   243 VLRFVT 248
            :.:..|
Human   264 LSQLET 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	22/58 (38%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	28/81 (35%)
KCNK17	NP_113648.2	Ion_trans_2	96..157	CDD:285168	23/61 (38%)
		Ion_trans_2	<203..268	CDD:285168	25/69 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..312
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155141
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840