Protein Alignment Task6 and Kcnd2

DIOPT Version :10

• Sequence 1: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_113918.2
• Gene: Kcnd2 / 65180
• RGDID: 68393
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 301
• Identity: 65/301 - (21%)
• Similarity: 117/301 - (38%)
• Gaps: 90/301 - (29%)

  Fly    28 ALESETEKRR-WEALQD--AEDMIIRKYNISQEDF--------KVMETVVL-KSESH----KAGQ 76
            ||.:.|.::| |.|.::  ...|.:..|.::  .|        .|:|||.. .|..|    ..|:
  Rat   161 ALPTMTARQRVWRAFENPHTSTMALVFYYVT--GFFIAVSVIANVVETVPCGSSPGHIKELPCGE 223

  Fly    77 QWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCY------------------------AIVG 117
              ::..||:...|....|              ||:.|                        ||:.
  Rat   224 --RYAVAFFCLDTACVMI--------------FTVEYLLRLAAAPSRYRFVRSVMSIIDVVAILP 272

  Fly   118 IPLGLVMFQS-------IGERVNRLSSYVIKAVRSSLRCK------RTVASEVDLICVVTTLSSL 169
            ..:||||..:       :..||.|:.. :.|..|.|...:      ::.|||:..:....|::.:
  Rat   273 YYIGLVMTDNEDVSGAFVTLRVFRVFR-IFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAII 336

  Fly   170 TIAGGAAAFSKFEGWSYFDSV----YYCFITLTTIGFGDMVALQRDNALNRKPEYV---MFALIF 227
            ..|.......|....|.|.|:    :|..:|:||:|:||||           |:.:   :|..|.
  Rat   337 IFATVMFYAEKGSSASKFTSIPAAFWYTIVTMTTLGYGDMV-----------PKTIAGKIFGSIC 390

  Fly   228 ILFGLAIVAASLNLLVLRFVTMNTEDERRDEAQAMQALQVA 268
            .|.|:.::|..:.::|..|..:..:::|.|:.:|.:..::|
  Rat   391 SLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLA 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	13/84 (15%)
		Ion_trans_2	165..243	CDD:462301	21/84 (25%)
Kcnd2	NP_113918.2	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000305|PubMed:14980206, ECO:0000305|PubMed:14980207	2..20
		BTB_POZ	6..144	CDD:453885
		Interaction with KCNIP1. /evidence=ECO:0000305|PubMed:14980207	71..90
		Ion_trans	184..415	CDD:459842	54/260 (21%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321		0/12 (0%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		2/4 (50%)
		DUF3399	470..546	CDD:463381
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000305|PubMed:16820361	474..630
		Required for dendritic targeting. /evidence=ECO:0000269|PubMed:12592409	474..489
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..623
		PDZ-binding. /evidence=ECO:0000269|PubMed:11923279, ECO:0000269|PubMed:14559911	627..630