DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Task6 and Kcnk1

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_067720.1	Gene:	Kcnk1 / 59324	RGDID:	621447	Length:	336	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	81/286 - (28%)
Similarity:	133/286 - (46%)	Gaps:	39/286 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LIVCTFTYLLVGAAVFDALESETE----------KRRW----EALQD--AEDMIIRKYNISQEDF 59
            |::....||:.||.||.::|...|          |||:    |.|.:  .|..:.|....|....
  Rat    26 LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGV 90

  Fly    60 KVMETVVLKSESHKAGQ-QWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLV 123
            .|:        |:.:|. .|.||.|.::|:|||:|.||||:.|.:.|||.|.:.|:::|||..|:
  Rat    91 SVL--------SNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLL 147

  Fly   124 MFQSIGERVNRLSSYVIKAVRSSLRCKRTVASEVDLICVVTTLSSLTIAG----GAAAFSKFE-G 183
            ...::   |.|::.:|.:........:...:.:|..|.....|..:|::.    .||.||..| .
  Rat   148 FLTAV---VQRVTVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDD 209

  Fly   184 WSYFDSVYYCFITLTTIGFGDMVALQRDNALNRK------PEYVMFALIFILFGLAIVAASLNLL 242
            |::.:|.|:|||:|:|||.||.|..:..|...|:      ..|::..||.:|..|........|.
  Rat   210 WNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELK 274

  Fly   243 VLRFVTMNTEDERRDEAQAMQALQVA 268
            ..|.:....:|:..|:...|:..|::
  Rat   275 KFRKMFYVKKDKDEDQVHIMEHDQLS 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	23/54 (43%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	28/88 (32%)
Kcnk1	NP_067720.1	Ion_trans_2	<101..157	CDD:400301	25/58 (43%)
		Selectivity filter 1. /evidence=ECO:0000250\|UniProtKB:O00180	117..122		3/4 (75%)
		Ion_trans_2	192..267	CDD:400301	25/74 (34%)
		Selectivity filter 2. /evidence=ECO:0000250\|UniProtKB:O00180	225..230		3/4 (75%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250\|UniProtKB:O00180	293..299		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840