DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Task6 and KCNK4

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001304019.1	Gene:	KCNK4 / 50801	HGNCID:	6279	Length:	393	Species:	Homo sapiens

Alignment Length:	286	Identity:	80/286 - (27%)
Similarity:	132/286 - (46%)	Gaps:	65/286 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYN-ISQEDFKVM---------- 62
            ::|:.....||:.||.||.|||...|::....|.:..:..:|.:. :|.::..::
Human     7 LALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGG 71

  Fly    63 ----ETVVLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLV 123
                ||....:.||.|   |....||:::.|::||||||:....|..|:||.:.||:|||||..:
Human    72 GADPETNSTSNSSHSA---WDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGI 133

  Fly   124 MFQSIGERVNRLSSYVIKAVRSSLR------------------CKRTVASEVDLI--CVVTTLSS 168
            :...:|:|:.           ||||                  ..|.:::.:.|:  |::..|:.
Human   134 LLAGVGDRLG-----------SSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTP 187

  Fly   169 LTIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVA---LQRDNALNRKPEYVMFALIFILF 230
            ..:      |...|.||..:::|:..:||||:||||.||   .::|:     |.|......:||.
Human   188 TFV------FCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDS-----PAYQPLVWFWILL 241

  Fly   231 GLAIVAASLNLL--VLRFVTMNTEDE 254
            |||..|:.|..:  .||.|:..|..|
Human   242 GLAYFASVLTTIGNWLRVVSRRTRAE 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	22/54 (41%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	27/82 (33%)
KCNK4	NP_001304019.1	Ion_trans_2	<88..142	CDD:400301	22/53 (42%)
		Selectivity filter 1. /evidence=ECO:0000269\|PubMed:22282805, ECO:0000269\|PubMed:23341632, ECO:0000269\|PubMed:25471887, ECO:0000269\|PubMed:25500157	103..108		4/4 (100%)
		Ion_trans_2	180..258	CDD:400301	27/88 (31%)
		Selectivity filter 2. /evidence=ECO:0000269\|PubMed:22282805, ECO:0000269\|PubMed:23341632, ECO:0000269\|PubMed:25471887, ECO:0000269\|PubMed:25500157	212..217		3/4 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..393
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840