DRSC/TRiP Functional Genomics Resources

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Protein Alignment Task6 and KCNK1

DIOPT Version :10

Sequence 1:NP_650300.2 Gene:Task6 / 41671 FlyBaseID:FBgn0038165 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_002236.1 Gene:KCNK1 / 3775 HGNCID:6272 Length:336 Species:Homo sapiens


Alignment Length:330 Identity:90/330 - (27%)
Similarity:144/330 - (43%) Gaps:70/330 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LIVCTFTYLLVGAAVFDALESETE----------KRRW----EAL--QDAEDMIIRKYNISQEDF 59
            |::....||:.||.||.::|...|          |||:    |.|  |..|..:.|....|....
Human    26 LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEQQLEQFLGRVLEASNYGV 90

  Fly    60 KVMETVVLKSESHKAGQ-QWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLV 123
            .|:        |:.:|. .|.||.|.::|:|||:|.||||:.|.:.|||.|.:.|:::|||..|:
Human    91 SVL--------SNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLL 147

  Fly   124 MFQSIGERVNRLSSYVIKAVRSSLRCKRTVASEVDLICVVTTLSSLTIAG----GAAAFSKFE-G 183
            ...::   |.|::.:|.:........:...:.:|..|.....|..:|::.    .||.||..| .
Human   148 FLTAV---VQRITVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDD 209

  Fly   184 WSYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMFALIFILFGLAIVAASLNLLVLR--- 245
            |::.:|.|:|||:|:|||.||.|..:..|...|: .|.:....::|.||..:     |:||.   
Human   210 WNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRE-LYKIGITCYLLLGLIAM-----LVVLETFC 268

  Fly   246 -----------FVTMNTEDERR---------------DEAQAMQALQVAVKLEGDVITSNGSILS 284
                       |.....:||.:               |:|..|:..|  .:.|..|.|.:.:.:.
Human   269 ELHELKKFRKMFYVKKDKDEDQVHIIEHDQLSFSSITDQAAGMKEDQ--KQNEPFVATQSSACVD 331

  Fly   285 GYEGH 289
            |...|
Human   332 GPANH 336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Task6NP_650300.2 Ion_trans_2 <78..132 CDD:462301 23/53 (43%)
Ion_trans_2 165..243 CDD:462301 27/82 (33%)
KCNK1NP_002236.1 Ion_trans_2 <98..157 CDD:462301 26/61 (43%)
pore-forming domain 107..123 9/15 (60%)
Ion_trans_2 191..267 CDD:462301 28/81 (35%)
pore-forming domain 212..238 12/25 (48%)
Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478 293..299 0/5 (0%)

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