Protein Alignment Task6 and KCNB1

DIOPT Version :10

• Sequence 1: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_004966.1
• Gene: KCNB1 / 3745
• HGNCID: 6231
• Length: 858
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 69/368 - (18%)
• Similarity: 135/368 - (36%)
• Gaps: 113/368 - (30%)

  Fly    31 SETEKRRWEALQDAEDMIIRK-YNISQEDFKVMETVVLKSES-------HKAGQ----------- 76
            :|..|:.|:.|:.....:..| ..|....|.|:.|:.|...:       .:.||
Human   169 AEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVE 233

  Fly    77 --------------------QWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLG 121
                                :|||......|..:|..:.|..:...|...|             .
Human   234 AVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNK-------------S 285

  Fly   122 LVMFQSIGE-----RVNRLSSYVIKAVRSSLRCK------RTVASEVDLICVVTTLSSLTIAGGA 175
            ::.||::..     |:.|:.. ::|..|.|...:      |...:|:.|:.       |.:|.|.
Human   286 VLQFQNVRRVVQIFRIMRILR-ILKLARHSTGLQSLGFTLRRSYNELGLLI-------LFLAMGI 342

  Fly   176 AAFS-------KFEGWSYFDSV----YYCFITLTTIGFGDMVALQRDNALNRKPEYVMFALI--- 226
            ..||       |.|..:.|.|:    ::..||:||:|:||:.           |:.::..::
Human   343 MIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIY-----------PKTLLGKIVGGL 396

  Fly   227 FILFGLAIVAASLNLLVLRFVTMNTEDERRDEA-QAMQALQVAVKLEGDVITSNGSILSGYEGHD 290
            ..:.|:.::|..:.::|..|.....|.:|:::| :..:||:.|.:        ||||:|
Human   397 CCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKR--------NGSIVS------ 447

  Fly   291 GQSLNGSNTSSMCSCHCIC-LNGNRHKKSSNLEKNNDAENQYK 332
             .::..:...|:.....:. .||....|...::.|:.:.|::|
Human   448 -MNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDNHLSPNKWK 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	10/58 (17%)
		Ion_trans_2	165..243	CDD:462301	19/91 (21%)
KCNB1	NP_004966.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		BTB_POZ_KCNB2	15..141	CDD:349719
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	59..75
		Ion_trans	188..424	CDD:459842	48/267 (18%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	377..382		2/4 (50%)
		Self-association. /evidence=ECO:0000250|UniProtKB:P15387	448..481		4/32 (13%)
		Kv2channel	467..679	CDD:397541	6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..524		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	538..574
		FFAT. /evidence=ECO:0000269|PubMed:33124732	590..596
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	770..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	836..858