DRSC/TRiP Functional Genomics Resources

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Protein Alignment Task6 and KCNK18

DIOPT Version :10

Sequence 1:NP_650300.2 Gene:Task6 / 41671 FlyBaseID:FBgn0038165 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_862823.1 Gene:KCNK18 / 338567 HGNCID:19439 Length:384 Species:Homo sapiens


Alignment Length:350 Identity:80/350 - (22%)
Similarity:117/350 - (33%) Gaps:137/350 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 TYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDFKVM---ETVV------LKSESH 72
            ||.||||.||.|:|.      .:.|..|:|....|:  .:|..:::   ||||      |:....
Human    32 TYALVGAVVFSAIED------GQVLVAADDGEFEKF--LEELCRILNCSETVVEDRKQDLQGHLQ 88

  Fly    73 KAGQQ-------WKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIGE 130
            |...|       |.|..:.::..||.:|:|||:..|.|..||...|.||:.||||..::....|:
Human    89 KVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGD 153

  Fly   131 --------RVNR-----------LSSYVIK----------------------------------- 141
                    ..||           ||.:..|                                   
Human   154 ILATILSTSYNRFRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCP 218

  Fly   142 ---------------------------AVRSSLRCKRTV------------------ASEVDLIC 161
                                       |:..|..|...|                  ...:|:..
Human   219 SRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLSYSIISNLDEVGQQVERLDIPL 283

  Fly   162 VVTTLSSLTIAGGAAAFSKFEGW----SYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVM 222
            .:..|........|||...|  |    .:.::.|:||:|||||||||.|.        ..|.:.:
Human   284 PIIALIVFAYISCAAAILPF--WETQLDFENAFYFCFVTLTTIGFGDTVL--------EHPNFFL 338

  Fly   223 FALIFILFGLAIVAASLNLLVLRFV 247
            |..|:|:.|:.||..:..|:..|.:
Human   339 FFSIYIIVGMEIVFIAFKLVQNRLI 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Task6NP_650300.2 Ion_trans_2 <78..132 CDD:462301 20/61 (33%)
Ion_trans_2 165..243 CDD:462301 27/81 (33%)
KCNK18NP_862823.1 Ion_trans_2 94..155 CDD:462301 20/60 (33%)
Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390 116..121 3/4 (75%)
Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64 200..205 0/4 (0%)
Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64 249..254 1/4 (25%)
Ion_trans_2 285..364 CDD:462301 28/88 (32%)
Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390 323..328 4/4 (100%)

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