DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Task6 and Kcnk3

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_203694.1	Gene:	Kcnk3 / 29553	RGDID:	61997	Length:	411	Species:	Rattus norvegicus

Alignment Length:	459	Identity:	181/459 - (39%)
Similarity:	249/459 - (54%)	Gaps:	104/459 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNISQEDFKVMETV 65
            ||:|||||::||||||||||||||||||||||.|....:.|:..:..:..:||:|:..::.:|.|
  Rat     1 MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPEMIERQRLELRQLELRARYNLSEGGYEELERV 65

  Fly    66 VLKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMFQSIGE 130
            ||:.:.||||.||:|.|:||:|.||:|||||||:.|||.|||:|.|.||::||||.||||||:||
  Rat    66 VLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGE 130

  Fly   131 RVNRLSSYVIKAVRSSLRCKRTVASEVDLICV--VTTLSSLTIAGGAAAFSKFEGWSYFDSVYYC 193
            |:|....|::...:..|..:....|..:::.:  |:.:|:|.|  ||||||.:|.|::|.:.|||
  Rat   131 RINTFVRYLLHRAKRGLGMRHAEVSMANMVLIGFVSCISTLCI--GAAAFSYYERWTFFQAYYYC 193

  Fly   194 FITLTTIGFGDMVALQRDNALNRKPEYVMFALIFILFGLAIVAASLNLLVLRFVTMNTEDERRD- 257
            |||||||||||.||||:|.||..:|:||.|:.::||.||.::.|.|||:||||:|||.|||:||
  Rat   194 FITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDA 258

  Fly   258 EAQAMQALQVAVKLEGDVITSNG--------SILSGYEGHD------------------GQSLNG 296
            |.:|:             :|.||        |.|||..|..                  |..:.|
  Rat   259 EHRAL-------------LTHNGQAGGLGGLSCLSGSLGDGVRPRDPVTCAAAAGGMGVGVGVGG 310

  Fly   297 S----------NTSSMCSCHCICLNGNRHKKSSNLEKNNDAENQYKLRQSPTHIRHLLPEVVPMQ 351
            |          :..|||||                       ..||.|:.   :::.:|.::| :
  Rat   311 SGFRNVYAEMLHFQSMCSC-----------------------LWYKSREK---LQYSIPMIIP-R 348

  Fly   352 DLNYD----------------YDTQSLHTLADRGTMDSSYMGVDMADMGDTGSMELRP-HTLLKR 399
            ||:..                |.....|.....||..|:...|      .||...|.. ..|:||
  Rat   349 DLSTSDTCVEHSHSSPGGGGRYSDTPSHPCLCSGTQRSAISSV------STGLHSLATFRGLMKR 407

  Fly   400 NVSL 403
            ..|:
  Rat   408 RSSV 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	38/54 (70%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	47/77 (61%)
Kcnk3	NP_203694.1	Ion_trans_2	<77..132	CDD:285168	38/54 (70%)
Kcnk3	NP_203694.1	Ion_trans_2	167..247	CDD:285168	48/81 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349013
Domainoid	1	1.000	112	1.000	Domainoid score	I6047
eggNOG	1	0.900	-	-		E1_KOG4404
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2654
OMA	1	1.010	-	-		QHG49311
OrthoDB	1	1.010	-	-		D1109218at2759
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		mtm9050
orthoMCL	1	0.900	-	-		OOG6_103570
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770