DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Task6 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_742039.1	Gene:	Kcnk2 / 170899	RGDID:	621448	Length:	426	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	93/286 - (32%)
Similarity:	143/286 - (50%)	Gaps:	53/286 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRKYNI--------SQE 57
            ||.:.|.||.|:|  ..||::||.||.|||...|      :.....::|:|.|.        |.|
  Rat    57 MKWKTVSTIFLVV--VLYLIIGATVFKALEQPQE------ISQRTTIVIQKQNFIAQHACVNSTE 113

  Fly    58 DFKVMETVV---------LKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCY 113
            ..::::.:|         |.:.|::. ..|....:|::|.||:||||:|:.:|.|.|||:|.:.|
  Rat   114 LDELIQQIVTAINAGIIPLGNNSNQV-SHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIY 177

  Fly   114 AIVGIPLGLVMFQSIGERVNRLSSYVIKAVRSSL------RCKRTVASEVDLI---CVVTTLSSL 169
            |::||||...:...:|:::..:....|..|..:.      :.|..:.|.:..|   ||      |
  Rat   178 ALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCV------L 236

  Fly   170 TIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMF----ALIFILF 230
            .:|..|..|...||||..|::|:..||||||||||.||...|      .||:.|    ...:||.
  Rat   237 FVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSD------IEYLDFYKPVVWFWILV 295

  Fly   231 GLAIVAASLNLL--VLRFVTMNTEDE 254
            |||..||.|:::  .||.::..|::|
  Rat   296 GLAYFAAVLSMIGDWLRVISKKTKEE 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	23/54 (43%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	36/83 (43%)
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	23/57 (40%)
		Ion_trans_2	234..312	CDD:285168	36/89 (40%)
		Required for basal channel activity. /evidence=ECO:0000250\|UniProtKB:P97438	354..426
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250\|UniProtKB:P97438	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840