DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Task6 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_001262541.1	Gene:	Task6 / 41671	FlyBaseID:	FBgn0038165	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_001153322.1	Gene:	Kcnk2 / 16526	MGIID:	109366	Length:	426	Species:	Mus musculus

Alignment Length:	286	Identity:	92/286 - (32%)
Similarity:	141/286 - (49%)	Gaps:	53/286 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKKQNVRTISLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIRK---------YNISQ 56
            ||.:.|.||.|:|  ..||::||.||.|||...|      :.....::|:|         .|.::
Mouse    57 MKWKTVSTIFLVV--VLYLIIGATVFKALEQPQE------ISQRTTIVIQKQTFIAQHACVNSTE 113

  Fly    57 EDFKVMETVV--------LKSESHKAGQQWKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCY 113
            .|..:.:.|.        |.:.|::. ..|....:|::|.||:||||:|:.:|.|.|||:|.:.|
Mouse   114 LDELIQQIVAAINAGIIPLGNSSNQV-SHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIY 177

  Fly   114 AIVGIPLGLVMFQSIGERVNRLSSYVIKAVRSSL------RCKRTVASEVDLI---CVVTTLSSL 169
            |::||||...:...:|:::..:....|..|..:.      :.|..:.|.:..|   ||      |
Mouse   178 ALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCV------L 236

  Fly   170 TIAGGAAAFSKFEGWSYFDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMF----ALIFILF 230
            .:|..|..|...||||..|::|:..||||||||||.||...|      .||:.|    ...:||.
Mouse   237 FVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSD------IEYLDFYKPVVWFWILV 295

  Fly   231 GLAIVAASLNLL--VLRFVTMNTEDE 254
            |||..||.|:::  .||.::..|::|
Mouse   296 GLAYFAAVLSMIGDWLRVISKKTKEE 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_001262541.1	Ion_trans_2	<77..132	CDD:285168	23/54 (43%)
Task6	NP_001262541.1	Ion_trans_2	169..247	CDD:285168	36/83 (43%)
Kcnk2	NP_001153322.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Ion_trans_2	<139..196	CDD:285168	23/57 (40%)
		Ion_trans_2	234..312	CDD:285168	36/89 (40%)
		Required for basal channel activity	369..426
		Essential for chloroform and halothane sensitivity	393..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840