Protein Alignment Task6 and Kcnk6

DIOPT Version :10

• Sequence 1: NP_650300.2
• Gene: Task6 / 41671
• FlyBaseID: FBgn0038165
• Length: 408
• Species: Drosophila melanogaster
• Sequence 2: NP_446258.2
• Gene: Kcnk6 / 116491
• RGDID: 621450
• Length: 313
• Species: Rattus norvegicus
• Alignment Length: 257
• Identity: 70/257 - (27%)
• Similarity: 126/257 - (49%)
• Gaps: 23/257 - (8%)

  Fly    10 SLIVCTFTYLLVGAAVFDALESETEKRRWEALQDAEDMIIR------KYNISQEDFKVMET---- 64
            |.:|....||.:||.:...||...|.|....|....:.::|      .:.:.....:|:..
  Rat     9 SALVAYAGYLALGALLVARLERPHEARLRAELGTLREQLLRHSPCVAAHALDAFVERVLAAGRLG 73

  Fly    65 -VVLKSESHKAGQQ---WKFTGAFYYATTVLTTIGYGHSTPSTVGGKLFTMCYAIVGIPLGLVMF 125
             .||.:.|..|...   |.|..|.::|:|::||:|||::||.|..||.|::.:|::|:|:.:::.
  Rat    74 RAVLANASGPANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLL 138

  Fly   126 QSIGERVNRLSSYV---IKAVRSSLRCKRTVASEVDLICVVTTLSSLTIAGGAAAFSKF-EGWSY 186
            .:..:|::.|.::.   ..::|.....:|  |:...|:.::..:.::.....||.|:.. |.||:
  Rat   139 TASAQRLSLLLTHAPLSWLSLRWGWHPQR--AARWHLVALLMVIVAIFFLIPAAVFAYLEEAWSF 201

  Fly   187 FDSVYYCFITLTTIGFGDMVALQRDNALNRKPEYVMFALIFILFGLAIVAASLNLLVLRFVT 248
            .|:.|:|||:|:|||.||.|..:......|. .|.:....::..||  ||..|.|...|.|:
  Rat   202 LDAFYFCFISLSTIGLGDYVPGEAPGQPYRS-LYKVLVTAYLFLGL--VAMVLVLQTFRRVS 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Task6	NP_650300.2	Ion_trans_2	<78..132	CDD:462301	19/53 (36%)
		Ion_trans_2	165..243	CDD:462301	26/78 (33%)
Kcnk6	NP_446258.2	Ion_trans_2	<89..146	CDD:462301	20/56 (36%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		3/4 (75%)
		Ion_trans_2	180..259	CDD:462301	27/81 (33%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	282..290
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	308..312