DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and RBM4B

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_113680.1	Gene:	RBM4B / 83759	HGNCID:	28842	Length:	359	Species:	Homo sapiens

Alignment Length:	209	Identity:	52/209 - (24%)
Similarity:	83/209 - (39%)	Gaps:	57/209 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            ::::|.||....|:::...|:.||:..:..|...||||..||...|:||:..|:..:|.|..:.|
Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQ 134
            |.:                             |||:..|:           :|.|.|:|...:.|
Human    68 EAS-----------------------------KNKSKAST-----------KLHVGNISPTCTNQ 92

  Fly   135 DLKDYMRQAGEV-------TYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDR 192
            :|:....:.|.|       .||..|.:|..:.|          .||..||:||..|:|:|:....
Human    93 ELRAKFEEYGPVIECDIVKDYAFVHMERAEDAV----------EAIRGLDNTEFQGKRMHVQLST 147

  Fly   193 RGGRSGGGGGSGRG 206
            ...|:..|.|...|
Human   148 SRLRTAPGMGDQSG 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	22/68 (32%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	22/77 (29%)
RBM4B	NP_113680.1	RRM1_RBM4	2..68	CDD:410018	20/64 (31%)
		RRM2_RBM4	78..144	CDD:410019	22/86 (26%)
		PTZ00368	<145..>181	CDD:173561	4/17 (24%)
		ZnF_C2HC	161..176	CDD:197667	1/1 (100%)
		Interaction with TNPO3. /evidence=ECO:0000250	196..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910