DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and Hnrnpm

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_084080.1	Gene:	Hnrnpm / 76936	MGIID:	1926465	Length:	729	Species:	Mus musculus

Alignment Length:	172	Identity:	55/172 - (31%)
Similarity:	71/172 - (41%)	Gaps:	27/172 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 GKELLGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKN---SRSSSRYGP---PLR 117
            |.|...|....||......|:......:...|.:|......|||.|.   .|..:|:.|   |.:
Mouse     4 GVEAAAEVAATEPKMEEESGAPCVPSGNGAPGPKGEERPTQNEKRKEKNIKRGGNRFEPYSNPTK 68

  Fly   118 TEYRLIVENLSSRVSWQDLKDYMRQ-AGEVTYA----DAHKQRRNEGVVEFASLSDMKTAIEKLD 177
             .||..:.|:...|.||.|||.::: .|||||.    ||..:.|...||||.....||.|.|.|:
Mouse    69 -RYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEESMKKAAEVLN 132

  Fly   178 DTELNGRRIHLVED------RR---------GGRSGGGGGSG 204
            ...|:||.:.:.||      ||         ||...|.||.|
Mouse   133 KHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPG 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	5/14 (36%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	29/75 (39%)
Hnrnpm	NP_084080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		15/60 (25%)
		HnRNP_M	40..69	CDD:288396	8/29 (28%)
		RRM1_hnRNPM	71..146	CDD:241101	28/74 (38%)
		RRM2_hnRNPM_like	205..278	CDD:240832
		27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]	399..607
		RRM3_hnRNPM	653..729	CDD:241105
		RRM	<654..>729	CDD:223796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900