DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and SRSF6

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_006266.2	Gene:	SRSF6 / 6431	HGNCID:	10788	Length:	344	Species:	Homo sapiens

Alignment Length:	359	Identity:	212/359 - (59%)
Similarity:	248/359 - (69%)	Gaps:	38/359 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            |||:|.|.|.|||:|::|||.||||..::.:|||||||||||.|||||||||||||||.||||:|
Human     3 RVYIGRLSYNVREKDIQRFFSGYGRLLEVDLKNGYGFVEFEDSRDADDAVYELNGKELCGERVIV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQ 134
            |.|||..|  :||.|.  ||.|.||||  |:.:..:.|  .:||||:||||||||||||||.|||
Human    68 EHARGPRR--DRDGYS--YGSRSGGGG--YSSRRTSGR--DKYGPPVRTEYRLIVENLSSRCSWQ 124

  Fly   135 DLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGRSGG 199
            ||||:||||||||||||||:|.||||:||.|.||||.|::|||.||:|||.|.|:||:  .|:.
Human   125 DLKDFMRQAGEVTYADAHKERTNEGVIEFRSYSDMKRALDKLDGTEINGRNIRLIEDK--PRTS- 186

  Fly   200 GGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRSRSNK 264
                  .|...|.||||||||||||||....|||:|||.|||   ||:|:|..|.||||||:..|
Human   187 ------HRRSYSGSRSRSRSRRRSRSRSRRSSRSRSRSISKS---RSRSRSRSKGRSRSRSKGRK 242

  Fly   265 SRDVSKSKSK----SHSRTRSRSPKRERDSRSRSRSVSKRES-----RSRSRSKSIHRDSR---- 316
            ||..||||.|    |||.:||||......|||||||.|.:|:     :|:|||:|..|.:.
Human   243 SRSKSKSKPKSDRGSHSHSRSRSKDEYEKSRSRSRSRSPKENGKGDIKSKSRSRSQSRSNSPLPV 307

  Fly   317 --SRDRSASAENK---SRSRSRSRSASPKNGNAS 345
              |:.||.|...|   |||||||||.|.....:|
Human   308 PPSKARSVSPPPKRATSRSRSRSRSKSRSRSRSS 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	50/68 (74%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	55/70 (79%)
SRSF6	NP_006266.2	RRM1_SRSF6	1..72	CDD:410009	50/68 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..103		13/35 (37%)
		RRM2_SRSF6	110..182	CDD:410159	56/71 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..344		87/178 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6142
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2259
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm42113
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1390
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.960