DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and SRSF4

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_005617.2	Gene:	SRSF4 / 6429	HGNCID:	10786	Length:	494	Species:	Homo sapiens

Alignment Length:	407	Identity:	212/407 - (52%)
Similarity:	252/407 - (61%)	Gaps:	80/407 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            |||:|.|.|..||||:||||||||:..::.:|||||||||:|.|||||||||||||:|.||||:|
Human     3 RVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDLCGERVIV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQ 134
            |.|||..|       |..||..|.|.|.|.:.::|       ||||.||||||||||||||.|||
Human    68 EHARGPRR-------DGSYGSGRSGYGYRRSGRDK-------YGPPTRTEYRLIVENLSSRCSWQ 118

  Fly   135 DLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGRSGG 199
            |||||||||||||||||||.|:||||:||.|.||||.|:||||.||:|||:|.||||:.|.|...
Human   119 DLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSRRRR 183

  Fly   200 GGGSGRGRSRSSSSRSRSRSRRRSRSR----RSSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRS 260
            .....|..||   ||||||..|:||||    :||||:|:|||||   |.||:|||..:|:|||||
Human   184 SYSRSRSHSR---SRSRSRHSRKSRSRSGSSKSSHSKSRSRSRS---GSRSRSKSRSRSQSRSRS 242

  Fly   261 RSNKSRDVSKSKSKSHS-------------------------RTRSRSPKRERD----------- 289
            :..|||..||.||:|.|                         :.:||||.|.:.
Human   243 KKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQER 307

  Fly   290 ----------SRSRSRSVSKRESRSRSRSKSIHRDSRSRDRSASAENK---------SRSRSRSR 335
                      ||.||:..|.|:||||||||...| ||||.||.|.:.:         ||||||||
Human   308 RVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSR-SRSRSRSKSKDKRKGRKRSREESRSRSRSR 371

  Fly   336 SASPKNGNASPDRNNES 352
            |.|.::......|::::
Human   372 SKSERSRKRGSKRDSKA 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	49/68 (72%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	58/70 (83%)
SRSF4	NP_005617.2	RRM1_SRSF4_like	3..72	CDD:240783	49/68 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..95		9/29 (31%)
		RRM2_SRSF4_like	104..175	CDD:241044	58/70 (83%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..494		90/227 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159208
Domainoid	1	1.000	113	1.000	Domainoid score	I6142
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2259
Isobase	1	0.950	-	0	Normalized mean entropy	S1097
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm42113
orthoMCL	1	0.900	-	-		OOG6_101955
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710