Protein Alignment B52 and SRSF3

DIOPT Version :10

• Sequence 1: NP_788671.2
• Gene: B52 / 41670
• FlyBaseID: FBgn0004587
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_003008.1
• Gene: SRSF3 / 6428
• HGNCID: 10785
• Length: 164
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 77/286 - (26%)
• Similarity: 95/286 - (33%)
• Gaps: 135/286 - (47%)

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKN---GYGFVEFEDYRDADDAVYELNGKELLGER 66
            :||||.|.....:.:|||.|..||..|.:.:..   |:.||||||.|||.|||.||:|:.|.|.|
Human    11 KVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCR 75

  Fly    67 VVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRV 131
            |.||.:.|..|..||                               |||               .
Human    76 VRVELSNGEKRSRNR-------------------------------GPP---------------P 94

  Fly   132 SWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDRRGGR 196
            ||
Human    95 SW--------------------------------------------------------------- 96

  Fly   197 SGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRSR 261
                     ||......|.||...||...||.|.|||:|||.|:.|.         :.||.||.|
Human    97 ---------GRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRR---------RERSLSRER 143

  Fly   262 SNKSRDVSKSKSKSHSRTRSRSPKRE 287
            ::|     .|:|.|.||:||||.:|:
Human   144 NHK-----PSRSFSRSRSRSRSNERK 164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_788671.2	RRM1_SRSF4_like	5..74	CDD:409774	34/71 (48%)
		RRM2_SRSF4_like	120..191	CDD:410012	2/70 (3%)
SRSF3	NP_003008.1	Sufficient for interaction with NXF1 and SRSP. /evidence=ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:32440474	1..90		36/78 (46%)
		RRM_SRSF3	6..86	CDD:241089	35/74 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..164		42/214 (20%)
		2 X approximate repeats, basic	119..164		24/58 (41%)