Protein Alignment B52 and SRSF1

DIOPT Version :9

• Sequence 1: NP_001014619.2
• Gene: B52 / 41670
• FlyBaseID: FBgn0004587
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_008855.1
• Gene: SRSF1 / 6426
• HGNCID: 10780
• Length: 248
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 120/265 - (45%)
• Similarity: 147/265 - (55%)
• Gaps: 42/265 - (15%)

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYG-----FVEFEDYRDADDAVYELNGKELLG 64
            |:|||.||..:|.:|:|..|..||..|||.:||..|     ||||||.|||:||||..:|.:..|
Human    17 RIYVGNLPPDIRTKDIEDVFYKYGAIRDIDLKNRRGGPPFAFVEFEDPRDAEDAVYGRDGYDYDG 81

  Fly    65 ERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPP-LRTEYRLIVENLS 128
            .|:.||..| :.||:.|       ||..|||||         ....||||| .|:|.|::|..|.
Human    82 YRLRVEFPR-SGRGTGR-------GGGGGGGGG---------APRGRYGPPSRRSENRVVVSGLP 129

  Fly   129 SRVSWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTEL---NGRRIHLVE 190
            ...|||||||:||:||:|.|||.:  |...|||||....||..|:.|||:|:.   .|...::..
Human   130 PSGSWQDLKDHMREAGDVCYADVY--RDGTGVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRV 192

  Fly   191 DRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSR 255
            ...|.||            .|..|||||||.|||||..|:|||:|.|..:|||  |...||..||
Human   193 KVDGPRS------------PSYGRSRSRSRSRSRSRSRSNSRSRSYSPRRSRG--SPRYSPRHSR 243

  Fly   256 SRSRS 260
            ||||:
Human   244 SRSRT 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	36/73 (49%)
		RRM2_SRSF4_like	120..191	CDD:241044	32/73 (44%)
SRSF1	NP_008855.1	RRM1_SRSF1	12..90	CDD:410010	36/72 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	88..134		21/62 (34%)
		RRM2_SRSF1	113..196	CDD:410160	37/84 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	191..248		33/70 (47%)
		Interaction with SAFB1	198..247		31/62 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1390
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840