Protein Alignment B52 and RBM4

DIOPT Version :10

• Sequence 1: NP_788671.2
• Gene: B52 / 41670
• FlyBaseID: FBgn0004587
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Alignment Length: 230
• Identity: 56/230 - (24%)
• Similarity: 89/230 - (38%)
• Gaps: 57/230 - (24%)

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            ::::|.||....|:::...|:.||:..:..|...||||..||...|:||:..|:..:|.|..:.|
Human     3 KLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRLIVENLSSRVSWQ 134
            |.:                             |||:           :|..:|.|.|:|...:.:
Human    68 EAS-----------------------------KNKS-----------KTSTKLHVGNISPTCTNK 92

  Fly   135 DLKDYMRQAGEV-------TYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDR 192
            :|:....:.|.|       .||..|.:|..:.|          .||..||:||..|:|:|:....
Human    93 ELRAKFEEYGPVIECDIVKDYAFVHMERAEDAV----------EAIRGLDNTEFQGKRMHVQLST 147

  Fly   193 RGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRR 227
            ...|:..|.|...|..|.......|:.....||.|
Human   148 SRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGR 182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_788671.2	RRM1_SRSF4_like	5..74	CDD:409774	22/68 (32%)
		RRM2_SRSF4_like	120..191	CDD:410012	21/77 (27%)
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	20/64 (31%)
		RRM2_RBM4	78..144	CDD:410019	21/75 (28%)
		PTZ00368	<145..>181	CDD:173561	7/35 (20%)
		ZnF_C2HC	161..176	CDD:197667	3/14 (21%)
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364