DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and Srsf4

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001356237.1	Gene:	Srsf4 / 57317	MGIID:	1890577	Length:	496	Species:	Mus musculus

Alignment Length:	368	Identity:	192/368 - (52%)
Similarity:	225/368 - (61%)	Gaps:	73/368 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 YGFVEFEDYRDADDAVYELNGKELLGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKN 103
            ||||||:|.|||||||||||||:|.||||:||.|||..|       |..||..|.|.|.|.:.::
Mouse    42 YGFVEFDDLRDADDAVYELNGKDLCGERVIVEHARGPRR-------DGSYGSGRSGYGYRRSGRD 99

  Fly   104 KNSRSSSRYGPPLRTEYRLIVENLSSRVSWQDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSD 168
            |       ||||.||||||||||||||.||||||||||||||||||||||.|:||||:||.|.||
Mouse   100 K-------YGPPTRTEYRLIVENLSSRCSWQDLKDYMRQAGEVTYADAHKGRKNEGVIEFVSYSD 157

  Fly   169 MKTAIEKLDDTELNGRRIHLVEDRRGGRSGGGGGSGRGRSRSSS-------SRSR------SRSR 220
            ||.|:||||.||:|||:|.||||:.|.|........|..|||.|       ||||      |.|:
Mouse   158 MKRALEKLDGTEVNGRKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSK 222

  Fly   221 RRSRSRRSSHSRSKSRSR--SKSRGGRSKSKSPVK-SRSRSRSRSNKSRDVSKSKSKSHS----- 277
            .|||||..||||||||||  |:||..:.||:||.| ::||||||   |.|.|:||||.|:
Mouse   223 SRSRSRSGSHSRSKSRSRSQSRSRSKKEKSRSPSKDNKSRSRSR---SPDKSRSKSKDHAEDKLQ 284

  Fly   278 ------RTRSRSPKRERDSRSRSRSVSKR--------------------------ESRSRSRSKS 310
                  :.:|.||.| .||:|||||..:|                          :||||||||.
Mouse   285 NNDSAGKAKSHSPSR-HDSKSRSRSQERRAEEERRRSVSRARSQEKSRSQEKSLLKSRSRSRSKV 348

  Fly   311 IHRD-SRSRD-RSASAENKSRSRSRSRSASPKNGNASPDRNNE 351
            ..|. |||:| |.....::..|||||||.|.::...|..|:::
Mouse   349 GSRSRSRSKDKRKGRKRSRDESRSRSRSKSERSRKHSSKRDSK 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	28/34 (82%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	58/70 (83%)
Srsf4	NP_001356237.1	RRM_SF	<42..77	CDD:388407	28/34 (82%)
		RRM2_SRSF4_like	109..180	CDD:241044	58/70 (83%)
		U2AF_lg	250..>361	CDD:273727	44/114 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849578
Domainoid	1	1.000	113	1.000	Domainoid score	I6120
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I2265
Isobase	1	0.950	-	0	Normalized mean entropy	S1097
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm44168
orthoMCL	1	0.900	-	-		OOG6_101955
Panther	1	1.100	-	-	O	PTHR23147
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.710