DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and Spen

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_006539132.1	Gene:	Spen / 56381	MGIID:	1891706	Length:	3644	Species:	Mus musculus

Alignment Length:	401	Identity:	107/401 - (26%)
Similarity:	142/401 - (35%)	Gaps:	116/401 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VYVGGLPYGVRERDLERFFKGYGRTRD--ILIKNG-----YGFVEFEDYRDADDAVYELNGKELL 63
            ::||.||..|||..:...||.|||...  ||.|.|     ..||:|.|.:.|..|...:|   .:
Mouse     8 LWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVN---KM 69

  Fly    64 GER----------VVVEPARG---TARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPP 115
            |:|          .:...|||   |...::|.|   ...|.||..||            ..||||
Mouse    70 GDRDLRTDYNEPGTIPSAARGLDETVSIASRSR---EVSGFRGSAGG------------PAYGPP 119

  Fly   116 L-------RTEYRL---------IVENLS-----------SRVSWQDLKDYMRQAGEVTYA---- 149
            .       |.|.||         ..|:.:           .|....| :||.|...|.|..
Mouse   120 PSLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGAFDRTRHYD-QDYYRDPRERTLQHGLY 183

  Fly   150 -----------DAHKQRRNEGVVE-FASLSDMKTAIEKLDDT-ELNGRRIHLVEDRRGGRSGGGG 201
                       |||..|......| |...|.:...|.:.|.| |:.|||
Mouse   184 YTSRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRR---------------- 232

  Fly   202 GSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSKSPVKSRSRSRSRSNKSR 266
                        ..||....||||..||.||::|..|..|:..| .::||..|.|||||.|:.|.
Mouse   233 ------------PERSYQHSRSRSPHSSQSRNQSPQRLASQASR-PTRSPSGSGSRSRSSSSDSI 284

  Fly   267 DVSKSKSKSHSRTRSRSPKRERDSRSRSRSVSKRESRSRSRSKSIHRDSRSRDRSASAENKSRSR 331
            . |.|.|.|::.:...|.....||.:||...:...:.:.....|:.:|...:......:|..
Mouse   285 S-SSSSSSSNTDSSDSSSTASDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLP--- 345

  Fly   332 SRSRSASPKNG 342
            .||...|.|:|
Mouse   346 VRSTDTSLKDG 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	26/84 (31%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	24/107 (22%)
Spen	XP_006539132.1	RRM1_SHARP	7..81	CDD:240794	25/75 (33%)
		U2AF_lg	128..596	CDD:273727	67/263 (25%)
		RRM2_SHARP	338..411	CDD:240795	6/22 (27%)
		RRM3_SHARP	438..511	CDD:240796
		RRM4_SHARP	512..588	CDD:240797
		PTZ00121	<635..1272	CDD:173412
		PHA03247	<1629..2063	CDD:223021
		PHA03247	<2122..2642	CDD:223021
		Collagen_mid	<2641..>2722	CDD:374271
		PHA03247	<2949..3474	CDD:223021
		SPOC	3483..3642	CDD:369497
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910