DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and PSPC1

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001035879.1	Gene:	PSPC1 / 55269	HGNCID:	20320	Length:	523	Species:	Homo sapiens

Alignment Length:	374	Identity:	72/374 - (19%)
Similarity:	127/374 - (33%)	Gaps:	73/374 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIK--NGYGFVEFEDYRDADDAVYELNGKELLGERV 67
            |::||.||..:.|.|.:|.|:.||...::.|.  .|:||:..|....|:.|..||:|..|
Human    83 RLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTIL----- 142

  Fly    68 VVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEY-----RLIVENL 127
                                                     .||   |||..:     .|.|:||
Human   143 -----------------------------------------KSR---PLRIRFATHGAALTVKNL 163

  Fly   128 SSRVSWQDLKDYMRQAGEVTYA----DAHKQRRNEGVVEFASLSDMKTAIEKLDDTEL---NGRR 185
            |..||.:.|:....|.|.|..|    |...:...:|.||||:....:.|:|:..|...   ...|
Human   164 SPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPR 228

  Fly   186 IHLVEDRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSR---------SRRSSHSRSKSRSRSKS 241
            ..:||.........|......:......:.|.:..|.::         ||..:....:.:.|.:.
Human   229 PVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQV 293

  Fly   242 RGGRSKSKSPVKSRSRSRSRSNKSRDVSKSKSKSHSRTRSRSPKRERDSRSRSRSVSKRESRSRS 306
            .....::|..:::...:....::...:.:...:.....|.....|.::.:.|.:...:.|...|.
Human   294 DRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRR 358

  Fly   307 RSKSIHRDSRSRDRSASAENKSRSRSRSRSASPKNGNASPDRNNESMDD 355
            |.:.:.|.....:.....|....:...:|....:.|:..| |...:|.|
Human   359 REEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGP-RGAINMGD 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	22/70 (31%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	23/82 (28%)
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:241030	27/116 (23%)
		Sufficient for paraspeckles localization	125..358		47/281 (17%)
		RRM2_PSP1	157..236	CDD:241033	24/78 (31%)
		NOPS_PSPC1	227..320	CDD:240584	10/92 (11%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269\|PubMed:16148043	231..358		13/126 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910