DRSC/TRiP Functional Genomics Resources

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Protein Alignment B52 and NCL

DIOPT Version :10

Sequence 1:NP_788671.2 Gene:B52 / 41670 FlyBaseID:FBgn0004587 Length:355 Species:Drosophila melanogaster
Sequence 2:NP_005372.2 Gene:NCL / 4691 HGNCID:7667 Length:710 Species:Homo sapiens


Alignment Length:349 Identity:70/349 - (20%)
Similarity:136/349 - (38%) Gaps:99/349 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VYVGGLPYGVRERDLERFFKGYGRTRDILIKNG-------------YGFVEFEDYRDADDAVYEL 57
            ::||.|.:.....:|:....      |:..||.             :|:|:||...|.:.|: ||
Human   309 LFVGNLNFNKSAPELKTGIS------DVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKAL-EL 366

  Fly    58 NGKELLGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSSSRYGPPLRTEYRL 122
            .|.::.|..:.:|..:                       |:.::|.:::|:             |
Human   367 TGLKVFGNEIKLEKPK-----------------------GKDSKKERDART-------------L 395

  Fly   123 IVENLSSRVSWQDLKDYMRQAGEVTYADAHKQRRNEGV--VEFASLSDMKTAIEKLDDTELNGRR 185
            :.:||..:|:..:||:....|.|:....  |..:::|:  :||.:.:|.:...|:...||::||.
Human   396 LAKNLPYKVTQDELKEVFEDAAEIRLVS--KDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRS 458

  Fly   186 IHLV--------EDRRGGRSGGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSR 242
            |.|.        :|.|||::....|..:....|:.|.|.:....:....:::..:.......||:
Human   459 ISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSK 523

  Fly   243 GG---------------RSKSKSPVKSRS------------RSRSRSNKSRDVSKSKSKSHSRTR 280
            |.               .|.:|..::.|:            .:||:.:|:..| |..|:.   |.
Human   524 GYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFV-KGLSED---TT 584

  Fly   281 SRSPKRERDSRSRSRSVSKRESRS 304
            ..:.|...|...|:|.|:.||:.|
Human   585 EETLKESFDGSVRARIVTDRETGS 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
B52NP_788671.2 RRM1_SRSF4_like 5..74 CDD:409774 18/80 (23%)
RRM2_SRSF4_like 120..191 CDD:410012 20/80 (25%)
NCLNP_005372.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..303
8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X 58..135
RRM1_NCL 307..381 CDD:409837 18/78 (23%)
RRM2_NCL 390..465 CDD:409838 21/89 (24%)
RRM3_NCL 485..557 CDD:409839 9/71 (13%)
RRM4_NCL 572..649 CDD:409840 13/41 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..710
Blue background indicates that the domain is not in the aligned region.

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