DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and HNRNPM

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_005959.2	Gene:	HNRNPM / 4670	HGNCID:	5046	Length:	730	Species:	Homo sapiens

Alignment Length:	181	Identity:	57/181 - (31%)
Similarity:	75/181 - (41%)	Gaps:	40/181 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 ADDAVYELNGKELLGERVVVEPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKN---SRSSSR 111
            |:.|..|:..:|..|       |.|...|:...      |.:..|.....|||.|.   .|..:|
Human     9 AEVAATEIKMEEESG-------APGVPSGNGAP------GPKGEGERPAQNEKRKEKNIKRGGNR 60

  Fly   112 YGP---PLRTEYRLIVENLSSRVSWQDLKDYMRQ-AGEVTYA----DAHKQRRNEGVVEFASLSD 168
            :.|   |.: .||..:.|:...|.||.|||.::: .|||||.    ||..:.|...||||.....
Human    61 FEPYANPTK-RYRAFITNIPFDVKWQSLKDLVKEKVGEVTYVELLMDAEGKSRGCAVVEFKMEES 124

  Fly   169 MKTAIEKLDDTELNGRRIHLVED------RR---------GGRSGGGGGSG 204
            ||.|.|.|:...|:||.:.:.||      ||         ||...|.||.|
Human   125 MKKAAEVLNKHSLSGRPLKVKEDPDGEHARRAMQKVMATTGGMGMGPGGPG 175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	6/23 (26%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	29/75 (39%)
HNRNPM	NP_005959.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..62		16/65 (25%)
		HnRNP_M	41..70	CDD:402915	8/29 (28%)
		RRM1_hnRNPM	72..147	CDD:410058	28/74 (38%)
		RRM2_hnRNPM	204..279	CDD:410060
		27 X 6 AA repeats of [GEVSTPAN]-[ILMV]-[DE]-[RH]-[MLVI]-[GAV]	400..608
		antiphage_ZorA_3	<414..553	CDD:411477
		RRM3_hnRNPM	654..730	CDD:410062
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0724
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810