DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment B52 and srsf6

DIOPT Version :9

Sequence 1:	NP_001014619.2	Gene:	B52 / 41670	FlyBaseID:	FBgn0004587	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001001248.1	Gene:	srsf6 / 407954	XenbaseID:	XB-GENE-488901	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	380	Identity:	212/380 - (55%)
Similarity:	255/380 - (67%)	Gaps:	53/380 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVGGLPYGVRERDLERFFKGYGRTRDILIKNGYGFVEFEDYRDADDAVYELNGKELLGERVVV 69
            |||:|.|.|.|||:|::|||.|||:..::.:|||||||||||.|||||||||||||:|.||||:|
Frog     3 RVYIGRLGYHVREKDIQRFFGGYGKLLEVDLKNGYGFVEFEDSRDADDAVYELNGKDLCGERVIV 67

  Fly    70 EPARGTARGSNRDRYDDRYGGRRGGGGGRYNEKNKNSRSS-SRYGPPLRTEYRLIVENLSSRVSW 133
            |.|||..|  :||.|.  ||.|.|         .:|.||. .:||||:|||:||||||||||.||
Frog    68 EHARGPRR--DRDGYG--YGSRSG---------YRNQRSGRDKYGPPVRTEFRLIVENLSSRCSW 119

  Fly   134 QDLKDYMRQAGEVTYADAHKQRRNEGVVEFASLSDMKTAIEKLDDTELNGRRIHLVEDR-RGGRS 197
            |||||:||||||||||||||:|.||||:||.|.||||.|:||||.||:|||||.|||.: |..||
Frog   120 QDLKDFMRQAGEVTYADAHKERANEGVIEFRSYSDMKRAMEKLDGTEINGRRIRLVEGKARHRRS 184

  Fly   198 GGGGGSGRGRSRSSSSRSRSRSRRRSRSRRSSHSRSKSRSRSKSRGGRSKSK------------- 249
            ..|     .|||   ||||||.|.|||||:.|||||:|||.|.::.|||.:|
Frog   185 YSG-----SRSR---SRSRSRRRSRSRSRQPSHSRSRSRSHSPAKKGRSPAKKSRSHSPTKSSHS 241

  Fly   250 -SPVKSRSRSRSRSNKSRDVSKSKSKSHSRTRSRSPKRERDSRSRSRSVSKR--------ESRSR 305
             ||.||:|||||||......||.||:..||:||.|..::..|||||:.:.:|        |.|||
Frog   242 QSPGKSQSRSRSRSRSKERASKPKSEHGSRSRSTSRGKQERSRSRSKGLVERSRSRSKENEERSR 306

  Fly   306 SRSKSIHRDSRSRDRSASAENKSRSRS-----RSRSASPKNGNASPDRNNESMDD 355
            ||||.:  |.|||.||.:.:::|||||     ||||.|....:.|..| :::.||
Frog   307 SRSKGM--DERSRSRSKTQDDRSRSRSKAKDDRSRSRSKAKDDRSRSR-SKAKDD 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
B52	NP_001014619.2	RRM1_SRSF4_like	5..74	CDD:240783	48/68 (71%)
B52	NP_001014619.2	RRM2_SRSF4_like	120..191	CDD:241044	57/70 (81%)
srsf6	NP_001001248.1	RRM1_SRSF6	3..72	CDD:241040	48/68 (71%)
		RRM2_SRSF4_like	106..176	CDD:241044	56/69 (81%)
		Rho	220..>403	CDD:333130	58/142 (41%)
		RRM	325..>453	CDD:330708	14/35 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	113	1.000	Domainoid score	I6077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2321
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1315388at2759
OrthoFinder	1	1.000	-	-		FOG0000217
OrthoInspector	1	1.000	-	-		otm49341
Panther	1	1.100	-	-	O	PTHR23147
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X517
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.160